Age and the aging process significantly alter the small bowel microbiome/Experiment 2
From BugSigDB
Reviewed Marked as Reviewed by Folakunmi on 2024-1-4
Subjects
- Location of subjects
- Switzerland
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Duodenum Proximal intestine,Upper intestine,Duodenum,duodenum
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Aging ageing,AGING BIOL,Aging, Biological,BIOL AGING,Biological Aging,Senescence,Aging,aging
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Group 1 (18–35 years old)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Group 3
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- participants aged 51 to 65 years old
- Group 0 sample size Number of subjects in the control (unexposed) group
- 32
- Group 1 sample size Number of subjects in the case (exposed) group
- 96
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Linear Regression
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- decreased
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- decreased
Signature 1
Reviewed Marked as Reviewed by Folakunmi on 2024-1-4
Source: Table S2
Description: Genera solely associated with age after multivariate analysis controlling for the number of medications used and the number of concomitant diseases.
Abundance in Group 1: increased abundance in Group 3
| NCBI | Quality Control | Links |
|---|---|---|
| Actinobacillus | ||
| Lactobacillus | ||
| Bacteroides | ||
| Escherichia |
Signature 2
Reviewed Marked as Reviewed by Folakunmi on 2024-1-4
Source: Table S2
Description: Genera solely associated with age after multivariate analysis controlling for the number of medications used and the number of concomitant diseases.
Abundance in Group 1: decreased abundance in Group 3
| NCBI | Quality Control | Links |
|---|---|---|
| Lysobacteraceae |
