Gut microbiota dysbiosis and diarrhea in kidney transplant recipients/Experiment 2
From BugSigDB
Reviewed Marked as Reviewed by Atrayees on 2023-6-6
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Diarrhea Diarrhea,Diarrhoea,Watery stool,diarrhea
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Antibiotic-excluded Controls (No Diarrhea Group)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Antibiotic-excluded Diarrhea Group
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Antibiotic-excluded diarrheal group; Kidney transplant recipients that developed post-transplant diarrhea within the first 3 months after transplantation
- Group 0 sample size Number of subjects in the control (unexposed) group
- 46
- Group 1 sample size Number of subjects in the case (exposed) group
- 13
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- Applicable; but exact duration not specified
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4-V5
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.15
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Matched on Factors on which subjects have been matched on in a case-control study
- antibiotic exposure
Signature 1
Reviewed Marked as Reviewed by Atrayees on 2023-6-6
Source: Table S2
Description: Differential microbial abundance between Antibiotic-excluded Controls and Antibiotic-excluded Diarrhea group
Abundance in Group 1: decreased abundance in Antibiotic-excluded Diarrhea Group
Revision editor(s): Ufuoma Ejite, Atrayees
Signature 2
Reviewed Marked as Reviewed by Atrayees on 2023-6-6
Source: Table S2
Description: Differential microbial abundance between Antibiotic-excluded Controls and Antibiotic-excluded Diarrhea group
Abundance in Group 1: increased abundance in Antibiotic-excluded Diarrhea Group
| NCBI | Quality Control | Links |
|---|---|---|
| Lachnoclostridium | ||
| Escherichia | ||
| Thomasclavelia | ||
| Blautia | ||
| Streptococcus |
Revision editor(s): Ufuoma Ejite, Atrayees
