The aging mouse microbiome has obesogenic characteristics/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Peace Sandy on 2024-2-20
Subjects
- Location of subjects
- Israel
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Mus musculus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces , Blood vessel Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces,Region of vascular tree organ,Vas sanguineum,Vascular element,Vascular tree organ region,Blood vessel,blood vessel
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Body weight weight,Body weight,body weight
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Adult
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Aging
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Aging Mice
- Group 0 sample size Number of subjects in the control (unexposed) group
- 42
- Group 1 sample size Number of subjects in the case (exposed) group
- 32
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- NIL
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- PERMANOVA
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Alpha Diversity
- Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
- increased
Signature 1
Reviewed Marked as Reviewed by LGeistlinger on 2023-11-11
Source: Figure 3
Description: Genera that differed significantly between adult and aged mice. Analysis of microbiome composition (ANCOM) revealed 6 genera a Dehalobacterium, b unspecified Peptococcaceae, c Sutterella, d unspecified Desulfovibrionaceae, and e Bilophila, with significantly different relative abundance in adult versus aged mice
Abundance in Group 1: increased abundance in Aging
| NCBI | Quality Control | Links |
|---|---|---|
| Dehalobacterium | ||
| Peptococcaceae | ||
| Sutterella | ||
| Desulfovibrionaceae | ||
| Bilophila |
Revision editor(s): Greatman, LGeistlinger, Peace Sandy
