Metabolic disorder and intestinal microflora dysbiosis in chronic inflammatory demyelinating polyradiculoneuropathy/Experiment 1
From BugSigDB
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Colon , Large intestine Hindgut,Large bowel,Posterior intestine,Colon,colon,Intestinum crassum,Large intestine,large intestine
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Chronic inflammatory demyelinating polyradiculoneuropathy chronic inflammatory demyelinating polyradiculoneuropathy,chronic inflammatory demyelinating polyradiculoneuropathy (disorder),chronic relapsing polyneuropathy,CIDP,Polyradiculoneuropathy, Chronic Inflammatory Demyelinating,Chronic inflammatory demyelinating polyradiculoneuropathy
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- non-CIDP subjects
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- CIDP subjects
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Chronic Inflammatory Demyelinating Polyneuropathy is a rare autoimmune disorder that affects the peripheral nerves. These are the nerves that carry signals from the brain and spinal cord to the muscles throughout the body. This damage disrupts the transmission of signals, which can cause weakness, numbness, pain, and fatigue.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 33
- Group 1 sample size Number of subjects in the case (exposed) group
- 31
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- DNBSEQ-T7
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- T-Test
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- Matched on Factors on which subjects have been matched on in a case-control study
- type I diabetes mellitus, type II diabetes mellitus, Matched on: "dyslipidemia" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.dyslipidemia, non-alcoholic fatty liver disease, Matched on: "neurodegenerative disorders" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.neurodegenerative disorders
Signature 1
Source: Fig 5
Description: Differentially abundant Microbiotic, identified between CIDP and non-CIDP Patients.
Abundance in Group 1: increased abundance in CIDP subjects
NCBI | Quality Control | Links |
---|---|---|
Klebsiella pneumoniae | ||
Escherichia coli | ||
Megamonas funiformis | ||
Phascolarctobacterium faecium |
Revision editor(s): Zheeburg
Signature 2
Source: Fig 5
Description: Differentially abundant Microbiotic, identified between CIDP and non-CIDP Patients.
Abundance in Group 1: decreased abundance in CIDP subjects
NCBI | Quality Control | Links |
---|---|---|
Bacteroides uniformis | ||
Phocaeicola dorei | ||
Phocaeicola vulgatus | ||
Bacteroides sp. A1C1Bacteroides sp. A1C1 |
Revision editor(s): Zheeburg