Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease/Experiment 2
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2024-4-5
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Mus musculus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Parkinson's disease IDIOPATHIC PARKINSON DIS,Idiopathic Parkinson Disease,Idiopathic Parkinson's Disease,IDIOPATHIC PARKINSONS DIS,Idiopathic PD,LEWY BODY PARKINSON DIS,Lewy Body Parkinson Disease,Lewy Body Parkinson's Disease,Paralysis agitans,paralysis agitans,PARKINSON DIS,PARKINSON DIS IDIOPATHIC,Parkinson disease,Parkinson Disease, Idiopathic,Parkinson syndrome,Parkinson's,Parkinson's disease,Parkinson's disease (disorder),Parkinson's disease NOS,Parkinson's disease NOS (disorder),Parkinson's Disease, Idiopathic,Parkinson's Disease, Lewy Body,Parkinson's syndrome,Parkinsonian disorder,Parkinsonism, Primary,Parkinsons,PARKINSONS DIS,PARKINSONS DIS IDIOPATHIC,PARKINSONS DIS LEWY BODY,Parkinsons disease,Primary Parkinsonism,parkinson's disease
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- ASO mice with fecal microbes from healthy controls (HC)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- ASO mice with fecal microbes from Parkinson’s disease patients (PD)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Germ-free mice, Thy1-α-synuclein genotype (ASO) colonized with fecal microbes from Parkinson’s disease patients (PD)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 6
- Group 1 sample size Number of subjects in the case (exposed) group
- 6
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- centered log-ratio
- Statistical test
- ANCOM
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2024-4-5
Source: Figure 6E
Description: Differentially abundant taxon in the ASO mice with HC fecal transfer and the ASO mice with PD fecal transfer.
Abundance in Group 1: increased abundance in ASO mice with fecal microbes from Parkinson’s disease patients (PD)
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroides | ||
| Bilophila | ||
| Enterococcus | ||
| Proteus | ||
| unsp.Veillonellaceaeunsp.Veillonellaceae | ||
| Peptococcaceae rc4-4 sp.Peptococcaceae rc4-4 sp. | ||
| Pseudoramibacter |
Revision editor(s): Svetlana up
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2024-4-5
Source: Figure 6E
Description: Differentially abundant taxon in the ASO mice with HC fecal transfer and the ASO mice with PD fecal transfer.
Abundance in Group 1: decreased abundance in ASO mice with fecal microbes from Parkinson’s disease patients (PD)
Revision editor(s): Svetlana up
