Comparison of Small Gut and Whole Gut Microbiota of First-Degree Relatives With Adult Celiac Disease Patients and Controls/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2024-5-30
Subjects
- Location of subjects
- India
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Duodenum Proximal intestine,Upper intestine,Duodenum,duodenum
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Celiac disease CD - Celiac disease,CD - Coeliac disease,CELIAC DIS,celiac disease,Celiac disease (disorder),Celiac disease NOS,Celiac disease NOS (disorder),Celiac rickets,Celiac rickets (disorder),Celiac Sprue,celiac sprue,Celiac syndrome,Coeliac disease,coeliac disease,Coeliac disease [Ambiguous],Coeliac disease NOS,Coeliac rickets,Coeliac sprue,Coeliac syndrome,CS - Celiac sprue,CS - Coeliac sprue,Disease, Celiac,Enteropathies, Gluten,Enteropathies, Gluten-Sensitive,Enteropathy, Gluten,Enteropathy, Gluten-Sensitive,Gluten Enteropathies,Gluten enteropathy,Gluten Sensitive Enteropathy,Gluten-Induced Enteropathy,gluten-induced enteropathy,Gluten-induced enteropathy syndrome,Gluten-responsive sprue,Gluten-Sensitive Enteropathies,Gluten-Sensitive Enteropathy,GSE - Gluten-sensitive enteropathy,Idiopathic steatorrhea,idiopathic steatorrhea,Idiopathic steatorrhoea,Non Tropical Sprue,non tropical sprue,Non-tropical sprue,Nontropical Sprue,Sprue,Sprue, Celiac,Sprue, Nontropical,Steatorrhoea - idiopathic,Wheat-sensitive enteropathy,Celiac disease
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Disease Control (DC)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- First-degree relatives (FDRs) of celiac disease (CeD) patients
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- First-degree relatives (FDRs) of celiac disease (CeD) patients genetically susceptible to celiac disease (CeD)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 14
- Group 1 sample size Number of subjects in the case (exposed) group
- 13
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- None
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- raw counts
- Statistical test
- DESeq2
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.01
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2024-5-30
Source: Figure 3A
Description: Comparison of differential abundance of microbial ASVs in duodenal microbiota of disease control (DC) group versus First-degree relatives (FDRs)
Abundance in Group 1: increased abundance in First-degree relatives (FDRs) of celiac disease (CeD) patients
Revision editor(s): Temi, Scholastica
Signature 2
Needs review
Source: Figure 3A
Description: Comparison of differential abundance of microbial ASVs in duodenal microbiota of disease control (DC) group versus First-degree relatives (FDRs)
Abundance in Group 1: decreased abundance in First-degree relatives (FDRs) of celiac disease (CeD) patients
| NCBI | Quality Control | Links |
|---|---|---|
| Turicibacter | ||
| Streptococcus | ||
| Ruminococcus | ||
| Moraxella | ||
| Methanomassiliicoccus | ||
| Lactobacillus | ||
| Intestinibacter | ||
| Eubacterium | ||
| Blautia | ||
| Barnesiella |
Revision editor(s): Temi, Scholastica
