A metagenomic study of the gut microbiome in Behcet's disease/Experiment 3
From BugSigDB
Reviewed Marked as Reviewed by ChiomaBlessing on 2024-3-29
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Response to transplant Response to transplant,response to transplant
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy Control feces treated group
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Behcet's disease (BD) feces treated group
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- B10RIII mice (mice undergoing autoimmune uveitis) colonized with untreated BD patients stool samples (experimental)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 4
- Group 1 sample size Number of subjects in the case (exposed) group
- 4
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- None
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- increased
Signature 1
Reviewed Marked as Reviewed by ChiomaBlessing on 2024-3-29
Source: Supplementary Figure S1c, Supplementary Table S9
Description: Abundance of altered genera in Behcet's disease (BD) patients’ feces treated group compared to healthy control feces treated mice
Abundance in Group 1: increased abundance in Behcet's disease (BD) feces treated group
| NCBI | Quality Control | Links |
|---|---|---|
| Alistipes | ||
| Alloprevotella | ||
| Anaerofilum | ||
| Bilophila | ||
| Butyricimonas | ||
| Coprobacter | ||
| Mucispirillum | ||
| Paraprevotella | ||
| Clostridium IVClostridium IV |
Revision editor(s): Fiddyhamma, ChiomaBlessing
Signature 2
Reviewed Marked as Reviewed by ChiomaBlessing on 2024-3-29
Source: Supplementary Figure S1c, Supplementary Table S9
Description: Abundance of altered genera in Behcet's disease (BD) patients’ feces treated group compared to healthy control feces treated mice
Abundance in Group 1: decreased abundance in Behcet's disease (BD) feces treated group
| NCBI | Quality Control | Links |
|---|---|---|
| Collinsella |
Revision editor(s): Fiddyhamma, ChiomaBlessing
