Association of fecal short-chain fatty acids with clinical severity and gut microbiota in essential tremor and its difference from Parkinson's disease/Experiment 2
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Reviewed Marked as Reviewed by Svetlana up on 2024-4-7
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Essential tremor benign essential tremor,benign essential tremor (disorder) [Ambiguous],essential hereditary tremor,essential tremor,Essential tremor (finding),shaky hand syndrome,tremor, hereditary essential,Essential tremor
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Parkinson's Disease
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Essential Tremor
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants face an action tremor of the upper limbs, possibly with the involvement of other parts of the body, such as the head, vocal cords, and lower limbs. Not only motor symptoms but also some nonmotor features, including gastrointestinal disorders, were experienced by them.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 37
- Group 1 sample size Number of subjects in the case (exposed) group
- 37
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- One month
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2024-4-7
Source: Figure 4, Table S5
Description: Examination of the fecal levels of SCFAs and linkage to changes in gut microbiota and symptom severity.
Abundance in Group 1: increased abundance in Essential Tremor
| NCBI | Quality Control | Links |
|---|---|---|
| Lachnoclostridium |
Revision editor(s): Nityasinghal 14, Svetlana up
