Interaction between Cervical Microbiota and Host Gene Regulation in Caesarean Section Scar Diverticulum/Experiment 1
From BugSigDB
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Endometrium , Uterine epithelium Tunica mucosa (endometrium),Tunica mucosa uteri,Uterine endometrium,Uterine mucosa,Uterine mucous membrane,Endometrium,endometrium,Uterus epithelium,Uterine epithelium,uterine epithelium
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Cesarean section caesarean section,Cesarean section,cesarean section
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy Control
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Cesarean Section Diverticulum
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients with a form of outpouching located in the anterior lower uterine cavity at the site of a cesarean section scar.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 28
- Group 1 sample size Number of subjects in the case (exposed) group
- 24
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 1 Month
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- increased
Signature 1
Source: figure 2
Description: Based on linear discriminant analysis (LDA), differential genus between the two groups were screened
Abundance in Group 1: increased abundance in Cesarean Section Diverticulum
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroides | ||
| Enterococcus | ||
| Escherichia/Shigella sp. | ||
| Gardnerella | ||
| Muribaculaceae | ||
| Paraburkholderia caballeronis | ||
| Prevotella | ||
| Ralstonia | ||
| Sphingomonas | ||
| Streptococcus |
Revision editor(s): Eve10111
Signature 2
Source: figure 2
Description: Based on linear discriminant analysis (LDA), differential genus between the two groups were screened
Abundance in Group 1: decreased abundance in Cesarean Section Diverticulum
| NCBI | Quality Control | Links |
|---|---|---|
| Lactobacillus | ||
| Faecalibaculum |
Revision editor(s): Eve10111
