Reviewed Marked as Reviewed by Svetlana up on 2024-7-1

Curated date: 2024/03/16

Curator: Samreen-19

Revision editor(s): WikiWorks, Scholastica, Samreen-19, Ifeanyisam

Subjects

Location of subjects
China
Singapore
Turkey
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Cognitive impairment Abnormality of cognition,Cognitive abnormality,Cognitive defects,Cognitive deficits,Cognitive impairment,Intellectual impairment,cognitive impairment
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Healthy group and Alzheimer's Disease (AD)
Group 1 name Corresponds to the case (exposed) group for case-control studies
Mild Cognitive Impairment (MCI)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Patients with mild cognitive impairment (MCI)
Group 0 sample size Number of subjects in the control (unexposed) group
228
Group 1 sample size Number of subjects in the case (exposed) group
141

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
LEfSe
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No
LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
3


Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2024-7-1

Curated date: 2024/03/16

Curator: Samreen-19

Revision editor(s): Samreen-19, Scholastica, WikiWorks

Source: Figure 3A

Description: Linear discriminant analysis (LDA) scores of the bacteria at the genus level significantly different in healthy group and mild cognitive impairment (MCI) versus Alzheimer’s disease (AD)

Abundance in Group 1: increased abundance in Mild Cognitive Impairment (MCI)

NCBI Quality ControlLinks
Blautia
Collinsella
Faecalibacterium
Lachnospira
Streptococcus
Thomasclavelia

Revision editor(s): Samreen-19, Scholastica, WikiWorks