Discuss Guild-Level Microbiome Signature Associated with COVID-19 Severity and Prognosis

It appears that there are repeated signatures in the curation and here is an excerpt from the paper explaining this.

"Among the 48 HQMAGs, 17 were significantly higher in the mild group compared to the moderate and severe/critical groups, and these showed a continuous decrease alongside the symptom severity. These 17 HQMAGs included 5 from Faecalibacterium prausnitzii, 3 from Romboutsia timonensis, 2 each from Ruminococcus and Clostridium, and 1 each from Acutalibacteraceae, Allisonella histaminiformans, Coprococcus, Lachnospiraceae, and Negativibacillus (Fig. 2A). The abundance of 31 out of the 48 HQMAGs identified by RDA was higher in the severe/critical group compared with the mild and the moderate groups. Among these 31 HQMAGs, 16 showed significant differences between the three groups. These 16 HQMAGs included 4 from Enterococcus, 2 from Lactobacillus, and 1 each from Acutalibacteraceae, Akkermansia muciniphila, Anaerotignum, Barnesiella intestinihominis, Clostridium bolteae, Dore, Intestinibacter bartlettii, Lachnospiraceae, Phascolarctobacterium faecium, and Ruthenibacterium lactatiformans (Fig. 2A). We then focused on the 17 mild group-enriched HQMAGs and 16 severe/critical group-enriched HQMAGs because they were all identified by RDA analysis and were significantly different between the 3 severity groups."