Toxic metals impact gut microbiota and metabolic risk in five African-origin populations/Experiment 1

From BugSigDB


Needs review

Curated date: 2025/05/05

Curator: PreciousChijioke

Revision editor(s): Chloe, Anne-mariesharp, PreciousChijioke

Subjects

Location of subjects
Ghana
Jamaica
Seychelles
South Africa
United States of America
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Metabolic toxicity Metabolic toxicity,metabolic toxicity
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Low lead exposure
Group 1 name Corresponds to the case (exposed) group for case-control studies
High lead exposure
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Participants with high lead exposure
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
3 months

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
LEfSe
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No
LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
3


Signature 1

Needs review

Curated date: 2025/07/28

Curator: Anne-mariesharp

Revision editor(s): Chloe, Anne-mariesharp

Source: Figure 2A

Description: Differential taxa by metal exposure.

Abundance in Group 1: increased abundance in High lead exposure

NCBI Quality ControlLinks
Clostridiaceae
Clostridium
Eubacteriales
Eubacterium coprostanoligenes
Peptostreptococcaceae
Romboutsia
Ruminococcus
Subdoligranulum
Peptostreptococcales-TissierellalesPeptostreptococcales-Tissierellales
UCG-005UCG-005

Revision editor(s): Chloe, Anne-mariesharp