Effects of Consuming Xylitol on Gut Microbiota and Lipid Metabolism in Mice/Experiment 1

From BugSigDB


Needs review

Curated date: 2025/07/02

Curator: YokoC

Revision editor(s): YokoC

Subjects

Location of subjects
Japan
Host species Species from which microbiome was sampled. Contact us to have more species added.
Mus musculus
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Response to diet Response to diet,response to diet
Group 0 name Corresponds to the control (unexposed) group for case-control studies
CD (Control diet)
Group 1 name Corresponds to the case (exposed) group for case-control studies
CD-LX (Low dose xylotil group)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Male mice that were given xylitol solution of 40 mg/kg body weight/day on a AIN93G 5% diet.
Group 0 sample size Number of subjects in the control (unexposed) group
5
Group 1 sample size Number of subjects in the case (exposed) group
5

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V2-V3

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
Post-Hoc Pairwise
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No


Signature 1

Needs review

Curated date: 2025/08/04

Curator: YokoC

Revision editor(s): YokoC

Source: Figure 2A

Description: Changes in the fecal microbiota of mice fed 40 ± 5 mg/kg body weight/day (CD-LX), and 194 ± 24 mg/kg body weight/day (CD-MX) of xylitol. An abundance of specific bacterial phylum or genus and ratio after seven weeks of xylitol supplementation.

Abundance in Group 1: increased abundance in CD-LX (Low dose xylotil group)

NCBI Quality ControlLinks
Bacillati
Bacteria

Revision editor(s): YokoC

Signature 2

incomplete

Curated date: 2025/08/04

Curator: YokoC

Revision editor(s): YokoC

Source: Figure 2A

Description: Changes in the fecal microbiota of mice fed 40 ± 5 mg/kg body weight/day (CD-LX), and 194 ± 24 mg/kg body weight/day (CD-MX) of xylitol. An abundance of specific bacterial phylum or genus and ratio after seven weeks of xylitol supplementation.

Abundance in Group 1: decreased abundance in CD-LX (Low dose xylotil group)

NCBI Quality ControlLinks
Bacteroides

Revision editor(s): YokoC