The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls/Experiment 3

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Reviewed Marked as Reviewed by Folakunmi on 2025-3-26

Curated date: 2025/03/25

Curator: Ese

Revision editor(s): Ese, Folakunmi

Subjects

Location of subjects
United Kingdom
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Constipation Constipation,Costiveness,Dyschezia,constipation
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Healthy participants at Baseline
Group 1 name Corresponds to the case (exposed) group for case-control studies
Constipated participants at Baseline
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Differences in fecal microbiota of Healthy and Constipated participants at Baseline
Group 0 sample size Number of subjects in the control (unexposed) group
8
Group 1 sample size Number of subjects in the case (exposed) group
16
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
1 Month

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V4-V5
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
Mann-Whitney (Wilcoxon)
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.1
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes


Signature 1

Reviewed Marked as Reviewed by Folakunmi on 2025-3-26

Curated date: 2025/03/25

Curator: Ese

Revision editor(s): Ese

Source: Table 2

Description: Taxonomic differences of fecal microbiota in Constipated patients and Healthy patients

Abundance in Group 1: increased abundance in Constipated participants at Baseline

NCBI Quality ControlLinks
Actinomyces
Adlercreutzia
Christensenella sp.
Clostridia incertae sedis
Desulfovibrio
Erysipelotrichaceae incertae sedis
Rhodococcus
uncultured Coriobacterium sp.

Revision editor(s): Ese

Signature 2

Reviewed Marked as Reviewed by Folakunmi on 2025-3-26

Curated date: 2025/03/26

Curator: Ese

Revision editor(s): Ese

Source: Table 2

Description: Taxonomic differences of fecal microbiota in Constipated patients and Healthy patients

Abundance in Group 1: decreased abundance in Constipated participants at Baseline

NCBI Quality ControlLinks
Lachnospira
SuterellaSuterella

Revision editor(s): Ese