The gut microbiota is associated with psychiatric symptom severity and treatment outcome among individuals with serious mental illness/Experiment 1
Curated date: 2021/01/10
Curator: WikiWorks
Revision editor(s): WikiWorks, ChiomaBlessing, Ifeanyisam
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Major depressive disorder major depression,major depressive disorder,recurrent major depression,single major depressive episode,unipolar depression,Major depressive disorder
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- mild depression
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- severe depression
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients in this group were diagnosed with severe depression (The primary patient-reported outcome measures used in this study were the Patient Health Questionnaire – 9 (PHQ-9) and the Patient Health Questionnaire – Generalized Anxiety Disorder screener (GAD-7); they were used to quantify depression severity).
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2
Signature 1
Source: Figure 1A and 1B
Description: Significant bacterial biomarkers among individuals with severe depression VS individuals with mild depression at admission
Abundance in Group 1: increased abundance in severe depression
| NCBI | Quality Control | Links |
|---|---|---|
| Flavonifractor plautii | ||
| Ruminococcus sp. | ||
| Lachnospiraceae bacterium 1_4_56FAA |
Revision editor(s): WikiWorks, Merit, ChiomaBlessing
Signature 2
Curated date: 2021/01/10
Curator: Fatima Zohra
Revision editor(s): WikiWorks, Rukky, ChiomaBlessing, Joan Chuks
Source: Figure 1A and 1B
Description: Significant bacterial biomarkers among individuals with severe depression VS individuals with mild depression at admission
Abundance in Group 1: decreased abundance in severe depression
Revision editor(s): WikiWorks, Rukky, ChiomaBlessing, Joan Chuks
