The composition of intestinal microbiota and its association with functional constipation of the elderly patients/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-4-4
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Chronic constipation Chronic constipation,Infrequent bowel movements,chronic constipation
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Heathy volunteers
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Functional constipation (FC) group
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients with functional constipation (FC)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 48
- Group 1 sample size Number of subjects in the case (exposed) group
- 61
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 3 months
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- T-Test
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- Matched on Factors on which subjects have been matched on in a case-control study
- age
Alpha Diversity
- Richness Number of species
- increased
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-4-4
Source: Figure 3B
Description: The intestinal microbiota composition between functional constipation patients and healthy controls at the genus level
Abundance in Group 1: increased abundance in Functional constipation (FC) group
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroides | ||
| Butyricimonas | ||
| Campylobacter | ||
| Candidatus Epulonipiscium | ||
| Clostridium | ||
| Rheinheimera | ||
| Sutterella |
Revision editor(s): Tosin
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-4-4
Source: Figure 3B
Description: The intestinal microbiota composition between functional constipation patients and healthy controls at the genus level
Abundance in Group 1: decreased abundance in Functional constipation (FC) group
| NCBI | Quality Control | Links |
|---|---|---|
| Akkermansia | ||
| Allobaculum | ||
| Atopobium | ||
| Dehalobacterium | ||
| Deinococcus | ||
| Edwardsiella | ||
| Escherichia | ||
| Lactococcus | ||
| Prevotella | ||
| Pseudomonas | ||
| Sphingomonas | ||
| Thermus | ||
| Veillonella |
Revision editor(s): Tosin
