Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by KateRasheed on 2025-6-12
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Kidney disease disease of kidney,disease or disorder of kidney,disorder of kidney,kidney disease,kidney disease or disorder,kidney diseases,Kidney Disorder,kidney disorder,nephropathy,renal disease,renal disorder,renal system disease,Kidney disease
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy Controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- End Stage Renal Disease (ESRD)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients diagnosed with End stage Renal Disease (ESRD) according to the Kidney Disease: Improving Global Outcomes Clinical Practice guidelines and were undergoing stable haemodialysis (1–3 times per week).
- Group 0 sample size Number of subjects in the control (unexposed) group
- 69
- Group 1 sample size Number of subjects in the case (exposed) group
- 223
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 1 month
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- decreased
Signature 1
Reviewed Marked as Reviewed by KateRasheed on 2025-6-12
Source: Figure 2B
Description: Differentially abundant Species between patients with End stage Renal disease (ESRD) and healthy controls.
Abundance in Group 1: increased abundance in End Stage Renal Disease (ESRD)
Revision editor(s): MyleeeA
Signature 2
Reviewed Marked as Reviewed by KateRasheed on 2025-6-12
Source: Figure 2B
Description: Differentially abundant Species between patients with End stage Renal disease (ESRD) and healthy controls.
Abundance in Group 1: decreased abundance in End Stage Renal Disease (ESRD)
Revision editor(s): MyleeeA
