Potential role of fecal microbiota in patients with constipation/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by KateRasheed on 2025-6-11
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Transplant outcome measurement Transplant outcome measurement,transplant outcome measurement
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Before treatment, After 1st treatment, After 2nd treatment, After 3rd treatment, 2 month follow-up and 3 month follow up
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Donor
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- The donors were healthy individuals without diseases or pathologic conditions potentially associated with changes in the gut microbiota.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 34
- Group 1 sample size Number of subjects in the case (exposed) group
- 4
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 1 month
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2
Signature 1
Reviewed Marked as Reviewed by KateRasheed on 2025-6-11
Source: Figure 5
Description: Linear discriminant analysis effect size (LEfSe) analysis of microbial abundance between Donor versus Before treatment, After 1st treatment, After 2nd treatment, After 3rd treatment, 2 month follow-up and 3 month follow up.
Abundance in Group 1: increased abundance in Donor
| NCBI | Quality Control | Links |
|---|---|---|
| Xanthobacteraceae | ||
| Asticcacaulis | ||
| Faecalibacterium | ||
| Dorea | ||
| Blautia | ||
| Anaerostipes | ||
| Lachnospiraceae | ||
| Oscillospiraceae |
Revision editor(s): MyleeeA
