Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson's disease/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-4-1
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Mus musculus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Treatment outcome measurement Treatment outcome measurement,treatment outcome measurement
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Control group
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- 6-hydroxydopamine (6-OHDA) group
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- 6-OHDA was injected into the right striatum to establish the Parkinson Disease mouse model. 6-OHDA is a hydroxylated analog of the natural dopamine neurotransmitter and used to destroy nigral dopaminergic neurons and deplete the striatum of DA neurotransmitter after the injection
- Group 0 sample size Number of subjects in the control (unexposed) group
- 12
- Group 1 sample size Number of subjects in the case (exposed) group
- 8
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- ANOVA
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- unchanged
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-4-1
Source: Figure 4D and Supplementary Table 5
Description: Different Relative Abundances of gut microbiota in 6-OHDA-induced vs Control
Abundance in Group 1: increased abundance in 6-hydroxydopamine (6-OHDA) group
| NCBI | Quality Control | Links |
|---|---|---|
| Bacillota | ||
| Lachnospiraceae | ||
| unclassified Eubacteriales | ||
| unclassified Lachnospiraceae | ||
| unclassified Rickenellaceae |
Revision editor(s): MyleeeA
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-4-1
Source: Figure 4D and Supplementary Table 5
Description: Different Relative Abundances of gut microbiota in 6-OHDA-induced vs Control
Abundance in Group 1: decreased abundance in 6-hydroxydopamine (6-OHDA) group
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroidota | ||
| Erysipelotrichaceae | ||
| Muribaculaceae | ||
| Rickenellaceae | ||
| unclassified Muribaculaceae |
Revision editor(s): MyleeeA
