Inferences in microbial structural signatures of acne microbiome and mycobiome/Experiment 3
From BugSigDB
Reviewed Marked as Reviewed by Folakunmi on 2023-12-19
Subjects
- Location of subjects
- South Korea
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Cheek , Forehead Buccae,Jowl,Cheek,cheek,Fore head,Sinciput,Forehead,forehead
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Acne acne,acne (disease),acne varioliformis,Acne Vulgaris,acne vulgaris,acne, ADULT,frontalis acne,Acne
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy group
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Acne group
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Korean women aged 19-28 years with acne, a common skin condition that affects the hair follicles and sebaceous (oil) glands in the skin.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 16
- Group 1 sample size Number of subjects in the case (exposed) group
- 17
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4-V5
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
Alpha Diversity
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- unchanged
- Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
- unchanged
Signature 1
Reviewed Marked as Reviewed by Folakunmi on 2023-12-19
Source: Within results text(Taxonomic signatures of acne in bacterial and fungal ASVs, paragraph 2),Figure S3C
Description: Result of linear discriminant analysis effect size (LEfSe) for fungi in the cheek microbiome between acne and healthy groups.
Abundance in Group 1: increased abundance in Acne group
| NCBI | Quality Control | Links |
|---|---|---|
| Densospora | ||
| Malassezia globosa |
Signature 2
Reviewed Marked as Reviewed by Folakunmi on 2023-12-19
Source: Within results text(Taxonomic signatures of acne in bacterial and fungal ASVs, paragraph 2), Figure S3C
Description: Result of linear discriminant analysis effect size (LEfSe) for fungi in the cheek microbiome between acne and healthy groups.
Abundance in Group 1: decreased abundance in Acne group
| NCBI | Quality Control | Links |
|---|---|---|
| Malassezia restricta | ||
| Malassezia slooffiae | ||
| Malasseziales | ||
| Saccharomyces cerevisiae |
