Alterations of bacteriome, mycobiome and metabolome characteristics in PCOS patients with normal/overweight individuals/Experiment 8

From BugSigDB


Reviewed Marked as Reviewed by KateRasheed on 2025-6-11

Curated date: 2025/05/07

Curator: Joiejoie

Revision editor(s): Joiejoie, Nithya, Anne-mariesharp

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Polycystic ovary syndrome Cystic disease of ovaries,hyperandrogenemia,Multicystic ovaries,multicystic ovaries,Ovarian Degeneration, Sclerocystic,Ovarian Syndrome, Polycystic,Ovarian Syndromes, Polycystic,Ovaries, Sclerocystic,Ovary Syndrome, Polycystic,Ovary, Sclerocystic,PCO - Polycystic ovaries,Pco1,PCOD - Polycystic ovarian disease,PCOS,Pcos,PCOS - Polycystic ovarian syndrome,PCOS1,Polycystic ovarian disease,polycystic ovarian disease,Polycystic ovarian syndrome,Polycystic ovaries,polycystic ovaries,Polycystic ovaries (disorder),polycystic ovary,polycystic ovary syndrome,polycystic ovary syndrome 1,Sclerocystic Ovarian Degeneration,Sclerocystic Ovaries,Sclerocystic Ovary,Sclerocystic Ovary Syndrome,Stein Leventhal Syndrome,Stein-Leventhal synd.,Stein-Leventhal Syndrome,Stein-Leventhal syndrome,Syndrome, Polycystic Ovary,Syndrome, Stein-Leventhal,Polycystic ovary syndrome
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Healthy-LB (Normal Body mass index) subjects
Group 1 name Corresponds to the case (exposed) group for case-control studies
PCOS-LB (Polycystic ovary syndrome - Normal Body mass index) patients
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group comprises Polycystic ovary syndrome (PCOS) patients with a body mass index (BMI < 24)
Group 0 sample size Number of subjects in the control (unexposed) group
21
Group 1 sample size Number of subjects in the case (exposed) group
22

Lab analysis

Sequencing type
ITS / ITS2
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
LEfSe
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No
LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
2

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
decreased
Chao1 Abundance-based estimator of species richness
decreased

Signature 1

Reviewed Marked as Reviewed by KateRasheed on 2025-6-11

Curated date: 2025/05/09

Curator: Nithya

Revision editor(s): Nithya, Anne-mariesharp

Source: Additional file 2: Figure S4

Description: Reveal of characteristic fungal taxa based on LDA Effect Size (LEfSe) analysis. Comparison between Healthy-LB and PCOS-LB.

Abundance in Group 1: increased abundance in PCOS-LB (Polycystic ovary syndrome - Normal Body mass index) patients

NCBI Quality ControlLinks
Thyridium

Revision editor(s): Nithya, Anne-mariesharp

Signature 2

Reviewed Marked as Reviewed by KateRasheed on 2025-6-11

Curated date: 2025/05/09

Curator: Nithya

Revision editor(s): Nithya, Anne-mariesharp

Source: Additional file 2: Figure S4

Description: Reveal of characteristic fungal taxa based on LDA Effect Size (LEfSe) analysis. Comparison between Healthy-LB and PCOS-LB.

Abundance in Group 1: decreased abundance in PCOS-LB (Polycystic ovary syndrome - Normal Body mass index) patients

NCBI Quality ControlLinks
Ascosphaera
Bolbitius
Botryotrichum
Cephaliophora
Cylindrocarpon
Meyerozyma
Nectria
Neurospora
Sarocladium
Setophoma
Solicoccozyma
Stagonosporopsis
Tetracladium
Westerdykella

Revision editor(s): Nithya, Anne-mariesharp