Diagnostic and prognostic potential of the microbiome in ovarian cancer treatment response

From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-1-10
Citation
PMID PubMed identifier for scientific articles.
DOI Digital object identifier for electronic documents.
URI
Authors
Asangba AE, Chen J, Goergen KM, Larson MC, Oberg AL, Casarin J, Multinu F, Kaufmann SH, Mariani A, Chia N, Walther-Antonio MRS
Journal
Scientific reports
Year
2023
Ovarian cancer (OC) is the second most common gynecological malignancy and the fifth leading cause of death due to cancer in women in the United States mainly due to the late-stage diagnosis of this cancer. It is, therefore, critical to identify potential indicators to aid in early detection and diagnosis of this disease. We investigated the microbiome associated with OC and its potential role in detection, progression as well as prognosis of the disease. We identified a distinct OC microbiome with general enrichment of several microbial taxa, including Dialister, Corynebacterium, Prevotella, and Peptoniphilus in the OC cohort in all body sites excluding stool and omentum which were not sampled from the benign cohort. These taxa were, however, depleted in the advanced-stage and high-grade OC patients compared to early-stage and low-grade OC patients suggestive of decrease accumulation in advanced disease and could serve as potential indicators for early detection of OC. Similarly, we also observed the accumulation of these mainly pathogenic taxa in OC patients with adverse treatment outcomes compared to those without events and could also serve as potential indicators for predicting patients' responses to treatment. These findings provide important insights into the potential use of the microbiome as indicators in (1) early detection of and screening for OC and (2) predicting patients' response to treatment. Given the limited number of patients enrolled in the study, these results would need to be further investigated and confirmed in a larger study.

Experiment 1


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Subjects

Location of subjects
United States of America
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Vagina , Uterine cervix Distal oviductal region,Distal portion of oviduct,Vaginae,Vagina,vagina,Canalis cervicis uteri,Caudal segment of uterus,Cervical canal,Cervical canal of uterus,Cervix,Cervix of uterus,Cervix uteri,Neck of uterus,Uterine cervix,uterine cervix
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Ovarian cancer cancer of ovary,cancer of the ovary,malignant neoplasm of ovary,malignant neoplasm of the ovary,malignant ovarian neoplasm,malignant ovarian tumor,malignant ovary neoplasm,malignant tumor of ovary,malignant tumor of the ovary,malignant tumour of ovary,ovarian cancer,ovarian cancer, epithelial,ovarian malignant tumor,ovarian neoplasm,ovary cancer,ovary neoplasm,primary ovarian cancer,tumor of the ovary,Ovarian cancer
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Benign
Group 1 name Corresponds to the case (exposed) group for case-control studies
Ovarian cancer
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Ovarian cancer refers to women with Ovarian cancer who are currently undergoing hysterectomy
Group 0 sample size Number of subjects in the control (unexposed) group
30
Group 1 sample size Number of subjects in the case (exposed) group
34
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
2 weeks

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V5
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
centered log-ratio
Statistical test
Linear Regression
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.10
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes
Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
body mass index, menopause

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
increased

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Fig. 2M, Supplementary Table 1, Supplementary Table 3

Description: Differential abundance of taxa between Benign and Ovarian cancer patients, gotten from Lower reproductive tract (vaginal and cervical samples)

Abundance in Group 1: increased abundance in Ovarian cancer

NCBI Quality ControlLinks
Corynebacterium tuberculostearicum
Facklamia hominis
Mediterraneibacter faecis
[Ruminococcus] torques
Corynebacterium
Facklamia

Revision editor(s): KateRasheed, WikiWorks

Experiment 2


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Ovary Animal ovary,Female gonad,Female organism genitalia gonad,Female organism genitalia gonada,Female organism reproductive system gonad,Female organism reproductive system gonada,Female reproductive system gonad,Female reproductive system gonada,Genitalia of female organism gonad,Genitalia of female organism gonada,Gonad of female organism genitalia,Gonad of female organism reproductive system,Gonad of female reproductive system,Gonad of genitalia of female organism,Gonad of reproductive system of female organism,Gonada of female organism genitalia,Gonada of female organism reproductive system,Gonada of female reproductive system,Gonada of genitalia of female organism,Gonada of reproductive system of female organism,Ovaries,Ovarium,Ovum-producing ovary,Reproductive system of female organism gonad,Reproductive system of female organism gonada,Ovary,ovary


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Fig. 2N, Supplementary Table 1, Supplementary Table 3

Description: Differential abundance of taxa between Benign and Ovarian cancer patients, gotten from the ovaries

Abundance in Group 1: decreased abundance in Ovarian cancer

NCBI Quality ControlLinks
Actinomycetota
Microbacterium lacus

Revision editor(s): KateRasheed, WikiWorks

Experiment 3


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Peritoneal fluid Peritoneal fluid,peritoneal fluid


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Fig. 2O, Supplementary Table 1, Supplementary Table 3

Description: Differential abundance of taxa between Benign and Ovarian cancer patients, gotten from Ascites/Peritoneal fluid

Abundance in Group 1: increased abundance in Ovarian cancer

NCBI Quality ControlLinks
Methylorubrum extorquens
Methylobacterium

Revision editor(s): KateRasheed, WikiWorks

Experiment 4


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Vagina , Uterine cervix Distal oviductal region,Distal portion of oviduct,Vaginae,Vagina,vagina,Canalis cervicis uteri,Caudal segment of uterus,Cervical canal,Cervical canal of uterus,Cervix,Cervix of uterus,Cervix uteri,Neck of uterus,Uterine cervix,uterine cervix
Group 1 name Corresponds to the case (exposed) group for case-control studies
Early Stage Ovarian Cancer (Early Stage OC)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Early Stage Ovarian Cancer (Early Stage OC) refers to patients at their early stage of ovarian cancer.
Group 1 sample size Number of subjects in the case (exposed) group
5

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
increased
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 4

Description: Differential abundance of taxa between Benign and Early Stage Ovarian cancer patients, gotten from Lower reproductive tract (vaginal and cervical samples)

Abundance in Group 1: increased abundance in Early Stage Ovarian Cancer (Early Stage OC)

NCBI Quality ControlLinks
Corynebacterium singulare
Corynebacterium sp.
Corynebacterium tuberculostearicum
Facklamia hominis
Fenollaria massiliensis
Fusicatenibacter saccharivorans
Mediterraneibacter faecis
Peptoniphilus koenoeneniae
uncultured Dialister sp.
Dialister
Facklamia
Ezakiella
Actinomycetota
Corynebacterium
Peptoniphilus
Fusicatenibacter
[Ruminococcus] torques

Revision editor(s): KateRasheed, WikiWorks

Experiment 5


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Urine Urine,urine


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 4

Description: Differential abundance of taxa between Benign and Early Stage Ovarian cancer patients, gotten from urine

Abundance in Group 1: increased abundance in Early Stage Ovarian Cancer (Early Stage OC)

NCBI Quality ControlLinks
Anaeroglobus
Anaeroglobus geminatus
Dialister
Dialister propionicifaciens

Revision editor(s): KateRasheed, WikiWorks

Experiment 6


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Vagina , Uterine cervix Distal oviductal region,Distal portion of oviduct,Vaginae,Vagina,vagina,Canalis cervicis uteri,Caudal segment of uterus,Cervical canal,Cervical canal of uterus,Cervix,Cervix of uterus,Cervix uteri,Neck of uterus,Uterine cervix,uterine cervix
Group 1 name Corresponds to the case (exposed) group for case-control studies
Advanced Stage Ovarian Cancer
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Advanced Stage Ovarian Cancer refers to patients at the advanced stage of ovarian cancer.
Group 1 sample size Number of subjects in the case (exposed) group
29

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
decreased
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 5

Description: Differential abundance of taxa between Benign and Advanced Stage Ovarian cancer patients, gotten from Lower reproductive tract (vaginal and cervical samples)

Abundance in Group 1: increased abundance in Advanced Stage Ovarian Cancer

NCBI Quality ControlLinks
Corynebacterium
Corynebacterium tuberculostearicum

Revision editor(s): KateRasheed, WikiWorks

Experiment 7


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Peritoneal fluid Peritoneal fluid,peritoneal fluid


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
decreased
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 5

Description: Differential abundance of taxa between Benign and Advanced Stage Ovarian cancer patients, gotten from Ascites/Peritoneal fluid

Abundance in Group 1: increased abundance in Advanced Stage Ovarian Cancer

NCBI Quality ControlLinks
Methylorubrum extorquens
Methylobacterium

Revision editor(s): KateRasheed, WikiWorks

Experiment 8


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Ovary Animal ovary,Female gonad,Female organism genitalia gonad,Female organism genitalia gonada,Female organism reproductive system gonad,Female organism reproductive system gonada,Female reproductive system gonad,Female reproductive system gonada,Genitalia of female organism gonad,Genitalia of female organism gonada,Gonad of female organism genitalia,Gonad of female organism reproductive system,Gonad of female reproductive system,Gonad of genitalia of female organism,Gonad of reproductive system of female organism,Gonada of female organism genitalia,Gonada of female organism reproductive system,Gonada of female reproductive system,Gonada of genitalia of female organism,Gonada of reproductive system of female organism,Ovaries,Ovarium,Ovum-producing ovary,Reproductive system of female organism gonad,Reproductive system of female organism gonada,Ovary,ovary
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Early Stage Ovarian cancer
Group 0 sample size Number of subjects in the control (unexposed) group
5

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 6

Description: Differential abundance of taxa between Advanced and Early Stage Ovarian cancer patients, gotten from Ovaries

Abundance in Group 1: decreased abundance in Advanced Stage Ovarian Cancer

NCBI Quality ControlLinks
Microbacterium lacus
Actinomycetota

Revision editor(s): KateRasheed, WikiWorks

Experiment 9


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Vagina , Uterine cervix Distal oviductal region,Distal portion of oviduct,Vaginae,Vagina,vagina,Canalis cervicis uteri,Caudal segment of uterus,Cervical canal,Cervical canal of uterus,Cervix,Cervix of uterus,Cervix uteri,Neck of uterus,Uterine cervix,uterine cervix


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
decreased
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 6

Description: Differential abundance of taxa between Advanced and Early Stage Ovarian cancer patients, gotten from Lower reproductive tract (vaginal and cervical samples)

Abundance in Group 1: decreased abundance in Advanced Stage Ovarian Cancer

NCBI Quality ControlLinks
Corynebacterium sp.
uncultured Dialister sp.
Corynebacterium
Dialister

Revision editor(s): KateRasheed, WikiWorks

Experiment 10


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Urine Urine,urine


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 6

Description: Differential abundance of taxa between Advanced and Early Stage Ovarian cancer patients, gotten from urine.

Abundance in Group 1: decreased abundance in Advanced Stage Ovarian Cancer

NCBI Quality ControlLinks
Anaeroglobus geminatus
Dialister propionicifaciens
Hallella bergensis
uncultured Prevotella sp.
Prevotella
Prevotella 6Prevotella 6
Dialister
Anaeroglobus

Revision editor(s): KateRasheed, WikiWorks

Experiment 11


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Uterus Uterus,uterus


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 6

Description: Differential abundance of taxa between Advanced and Early Stage Ovarian cancer patients, gotten from uterus

Abundance in Group 1: decreased abundance in Advanced Stage Ovarian Cancer

NCBI Quality ControlLinks
Corynebacterium
Corynebacterium tuberculostearicum
Roseateles
Roseateles depolymerans

Revision editor(s): KateRasheed, WikiWorks

Experiment 12


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/16

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 6

Description: Differential abundance of taxa between Advanced and Early Stage Ovarian cancer patients, gotten from stool

Abundance in Group 1: decreased abundance in Advanced Stage Ovarian Cancer

NCBI Quality ControlLinks
Aedoeadaptatus nemausensis
Alistipes
Alistipes onderdonkii
Alistipes shahii
Anaerofilum
Anaeromassilibacillus sp.
Anaerotruncus sp.
Arcanobacterium
Arcanobacterium urinimassiliense
Bacillota
Bacteroides
Bacteroides caccae
Clostridium sp. CAG:352
Coriobacteriales bacterium DNF00809
Cutibacterium
Cutibacterium avidum
Eubacterium coprostanoligenes
Fastidiosipila
Fastidiosipila sanguinis
Fusobacterium
Fusobacterium nucleatum
Hoylesella buccalis
Hydrogenoanaerobacterium
Metaprevotella massiliensis
Mobiluncus
Mobiluncus curtisii
Murdochiella
Murdochiella sp. Marseille-P8839
Ndongobacter massiliensis
Negativicoccus
Negativicoccus succinicivorans
Peptococcus
Peptoniphilaceae bacterium
Peptoniphilus
Peptoniphilus duerdenii
Phascolarctobacterium
Phascolarctobacterium succinatutens
Porphyromonas
Porphyromonas bennonis
Prevotella
Staphylococcus
Staphylococcus epidermidis
rumen bacterium NK4A214
uncultured Anaerofilum sp.
uncultured Eubacteriales bacterium
uncultured Oscillospiraceae bacterium
uncultured Peptococcus sp.
uncultured Succiniclasticum sp.
uncultured Thermoanaerobacterales bacterium
uncultured Veillonella sp.
uncultured bacterium
Christensenellaceae R-7 groupChristensenellaceae R-7 group
Prevotella 7Prevotella 7
Ruminococcaceae UCG-002Ruminococcaceae UCG-002
Ruminococcaceae UCG-005Ruminococcaceae UCG-005
Ruminiclostridium 5Ruminiclostridium 5

Revision editor(s): KateRasheed, WikiWorks

Experiment 13


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Ovary Animal ovary,Female gonad,Female organism genitalia gonad,Female organism genitalia gonada,Female organism reproductive system gonad,Female organism reproductive system gonada,Female reproductive system gonad,Female reproductive system gonada,Genitalia of female organism gonad,Genitalia of female organism gonada,Gonad of female organism genitalia,Gonad of female organism reproductive system,Gonad of female reproductive system,Gonad of genitalia of female organism,Gonad of reproductive system of female organism,Gonada of female organism genitalia,Gonada of female organism reproductive system,Gonada of female reproductive system,Gonada of genitalia of female organism,Gonada of reproductive system of female organism,Ovaries,Ovarium,Ovum-producing ovary,Reproductive system of female organism gonad,Reproductive system of female organism gonada,Ovary,ovary
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Benign
Group 1 name Corresponds to the case (exposed) group for case-control studies
Low Grade Tumor
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Low Grade Tumor refers to patients with low-grade tumor
Group 0 sample size Number of subjects in the control (unexposed) group
30
Group 1 sample size Number of subjects in the case (exposed) group
5

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 7

Description: Differential abundance of taxa between Benign and Low grade tumor patients, gotten from ovaries

Abundance in Group 1: increased abundance in Low Grade Tumor

NCBI Quality ControlLinks
Achromobacter spanius
Achromobacter

Revision editor(s): KateRasheed, WikiWorks

Experiment 14


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Vagina , Uterine cervix Distal oviductal region,Distal portion of oviduct,Vaginae,Vagina,vagina,Canalis cervicis uteri,Caudal segment of uterus,Cervical canal,Cervical canal of uterus,Cervix,Cervix of uterus,Cervix uteri,Neck of uterus,Uterine cervix,uterine cervix


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 7

Description: Differential abundance of taxa between Benign and Low grade tumor patients, gotten from Lower reproductive tract (vaginal and cervical samples)

Abundance in Group 1: increased abundance in Low Grade Tumor

NCBI Quality ControlLinks
Aedoeadaptatus urinae
Agathobacter rectalis
Alistipes putredinis
Anaerobutyricum soehngenii
Anaerococcus vaginimassiliensis
Anaerostipes hadrus
Bacteroides fragilis
Bacteroides ovatus
Bacteroides thetaiotaomicron
Bacteroides uniformis
Blautia faecis
Blautia sp.
Blautia wexlerae
Collinsella aerofaciens
Corynebacterium amycolatum
Corynebacterium singulare
Corynebacterium sp.
Corynebacterium tuberculostearicum
Dermabacter jinjuensis
Dialister propionicifaciens
Dorea longicatena
Escherichia coli
Faecalibacterium prausnitzii
Fastidiosipila sanguinis
Fusicatenibacter saccharivorans
Fusobacterium nucleatum
Hallella bergensis
Hoylesella timonensis
Mediterraneibacter faecis
Mobiluncus curtisii
Murdochiella asaccharolytica
Negativicoccus succinicivorans
Olegusella massiliensis
Peptoniphilus harei
Peptoniphilus koenoeneniae
Peptostreptococcus anaerobius
Porphyromonas bennonis
Schaalia radingae
Schaalia turicensis
Staphylococcus aureus
Staphylococcus epidermidis
Streptococcus infantis
Streptococcus parasanguinis
Streptococcus sp.
Sutterella sp.
Varibaculum cambriense
[Ruminococcus] torques
uncultured Actinomycetales bacterium
uncultured Bacteroides sp.
uncultured Eubacteriales bacterium
uncultured Lachnoclostridium sp.
uncultured Lachnospiraceae bacterium
uncultured Peptococcus sp.
uncultured Peptoniphilus sp.
Varibaculum
Escherichia/Shigella sp.
Collinsella
Anaerococcus
Peptostreptococcus
Murdochiella
Peptoniphilus
Peptococcus
Fusobacterium
Alistipes
Bacteroides
Prevotella 6Prevotella 6
Prevotella
Mobiluncus
Porphyromonas
Fastidiosipila
Blautia
Anaerostipes
Dorea
Lachnoclostridium
Fusicatenibacter
Agathobacter
Anaerobutyricum hallii
Eubacterium coprostanoligenes
Faecalibacterium
Subdoligranulum
Sutterella
Actinomyces
Peptostreptococcaceae bacterium oral taxon 113 str. W5053
Corynebacterium
Actinomycetota
Dermabacter
Streptococcus
Staphylococcus
Dialister
Negativicoccus

Revision editor(s): KateRasheed, WikiWorks

Experiment 15


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
High Grade Tumor
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
High Grade Tumor refers to patients with high-grade tumor
Group 1 sample size Number of subjects in the case (exposed) group
29

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 8

Description: Differential abundance of taxa between Benign and High grade tumor patients, gotten from Lower reproductive tract (vaginal and cervical samples)

Abundance in Group 1: increased abundance in High Grade Tumor

NCBI Quality ControlLinks
Corynebacterium tuberculostearicum
Facklamia hominis
Corynebacterium
Facklamia

Revision editor(s): KateRasheed, WikiWorks

Experiment 16


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Ovary Animal ovary,Female gonad,Female organism genitalia gonad,Female organism genitalia gonada,Female organism reproductive system gonad,Female organism reproductive system gonada,Female reproductive system gonad,Female reproductive system gonada,Genitalia of female organism gonad,Genitalia of female organism gonada,Gonad of female organism genitalia,Gonad of female organism reproductive system,Gonad of female reproductive system,Gonad of genitalia of female organism,Gonad of reproductive system of female organism,Gonada of female organism genitalia,Gonada of female organism reproductive system,Gonada of female reproductive system,Gonada of genitalia of female organism,Gonada of reproductive system of female organism,Ovaries,Ovarium,Ovum-producing ovary,Reproductive system of female organism gonad,Reproductive system of female organism gonada,Ovary,ovary


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 8

Description: Differential abundance of taxa between Benign and High-grade tumor patients, gotten from ovaries

Abundance in Group 1: decreased abundance in High Grade Tumor

NCBI Quality ControlLinks
Microbacterium lacus
Actinomycetota

Revision editor(s): KateRasheed, WikiWorks

Experiment 17


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Peritoneal fluid Peritoneal fluid,peritoneal fluid


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 8

Description: Differential abundance of taxa between Benign and High grade tumor patients, gotten from Ascites/Peritoneal Fluid.

Abundance in Group 1: increased abundance in High Grade Tumor

NCBI Quality ControlLinks
Methylorubrum extorquens
Methylobacterium

Revision editor(s): KateRasheed, WikiWorks

Experiment 18


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Ovary Animal ovary,Female gonad,Female organism genitalia gonad,Female organism genitalia gonada,Female organism reproductive system gonad,Female organism reproductive system gonada,Female reproductive system gonad,Female reproductive system gonada,Genitalia of female organism gonad,Genitalia of female organism gonada,Gonad of female organism genitalia,Gonad of female organism reproductive system,Gonad of female reproductive system,Gonad of genitalia of female organism,Gonad of reproductive system of female organism,Gonada of female organism genitalia,Gonada of female organism reproductive system,Gonada of female reproductive system,Gonada of genitalia of female organism,Gonada of reproductive system of female organism,Ovaries,Ovarium,Ovum-producing ovary,Reproductive system of female organism gonad,Reproductive system of female organism gonada,Ovary,ovary
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Low Grade Tumor
Group 0 sample size Number of subjects in the control (unexposed) group
5

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 9

Description: Differential abundance of taxa between Low and High grade tumor patients, gotten from ovaries.

Abundance in Group 1: decreased abundance in High Grade Tumor

NCBI Quality ControlLinks
Achromobacter spanius
Achromobacter

Revision editor(s): KateRasheed, WikiWorks

Experiment 19


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Uterus Uterus,uterus


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 9

Description: Differential abundance of taxa between Low and High grade tumor patients, gotten from uterus.

Abundance in Group 1: decreased abundance in High Grade Tumor

NCBI Quality ControlLinks
Roseateles depolymerans
Roseateles

Revision editor(s): KateRasheed, WikiWorks

Experiment 20


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Urine Urine,urine


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 9

Description: Differential abundance of taxa between Low and High grade tumor patients, gotten from urine.

Abundance in Group 1: decreased abundance in High Grade Tumor

NCBI Quality ControlLinks
Anaerococcus murdochii
Anaerococcus sp. Marseille-P3915
Atopobium deltae
Dialister micraerophilus
Dialister propionicifaciens
Fenollaria massiliensis
Hallella bergensis
Hoylesella timonensis
Mobiluncus curtisii
Peptoniphilus duerdenii
Peptostreptococcus anaerobius
Porphyromonas bennonis
Varibaculum cambriense
uncultured Dialister sp.
uncultured Howardella sp.
uncultured Prevotella sp.
Varibaculum
Atopobium
Anaerococcus
Peptostreptococcus
Peptoniphilus
Prevotella 6Prevotella 6
Prevotella
Mobiluncus
Porphyromonas
Dialister
Howardella
Ezakiella
Bacillota

Revision editor(s): KateRasheed, WikiWorks

Experiment 21


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Vagina , Uterine cervix Distal oviductal region,Distal portion of oviduct,Vaginae,Vagina,vagina,Canalis cervicis uteri,Caudal segment of uterus,Cervical canal,Cervical canal of uterus,Cervix,Cervix of uterus,Cervix uteri,Neck of uterus,Uterine cervix,uterine cervix


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 9

Description: Differential abundance of taxa between Low and High grade tumor patients, gotten from Lower reproductive tract (vaginal and cervical samples)

Abundance in Group 1: decreased abundance in High Grade Tumor

NCBI Quality ControlLinks
Agathobacter rectalis
Alistipes putredinis
Anaerobutyricum soehngenii
Anaerostipes hadrus
Bacteroides ovatus
Bacteroides thetaiotaomicron
Bacteroides uniformis
Blautia faecis
Blautia sp.
Blautia wexlerae
Collinsella aerofaciens
Corynebacterium sp.
Dialister propionicifaciens
Escherichia coli
Faecalibacterium prausnitzii
Fusicatenibacter saccharivorans
Fusobacterium nucleatum
Hallella bergensis
Hoylesella timonensis
Mediterraneibacter faecis
Mobiluncus curtisii
Murdochiella asaccharolytica
Negativicoccus succinicivorans
Olegusella massiliensis
Peptoniphilus koenoeneniae
Peptostreptococcus anaerobius
Staphylococcus epidermidis
Streptococcus infantis
Streptococcus parasanguinis
Varibaculum cambriense
[Ruminococcus] torques
uncultured Actinomycetales bacterium
uncultured Bacteroides sp.
uncultured Eubacteriales bacterium
uncultured Lachnospiraceae bacterium
uncultured Peptococcus sp.
uncultured Peptoniphilus sp.
Escherichia/Shigella sp.
Varibaculum
Collinsella
Peptostreptococcus
Murdochiella
Peptoniphilus
Peptococcus
Fusobacterium
Alistipes
Bacteroides
Prevotella 6Prevotella 6
Prevotella
Mobiluncus
Blautia
Anaerostipes
Fusicatenibacter
Agathobacter
Eubacterium coprostanoligenes
Faecalibacterium
Corynebacterium
Actinomycetota
Bacillota
Anaerobutyricum hallii
Streptococcus
Staphylococcus
Peptostreptococcaceae bacterium oral taxon 113 str. W5053
Dialister
Negativicoccus

Revision editor(s): KateRasheed, WikiWorks

Experiment 22


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Benign
Group 1 name Corresponds to the case (exposed) group for case-control studies
Serous ovarian cancer
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Serous ovarian cancer is a type of ovarian cancer that forms in the tissue that lines the ovaries.
Group 0 sample size Number of subjects in the control (unexposed) group
30

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
increased
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 10

Description: Differential abundance of taxa between Benign and Serous ovarian cancer patients, gotten from Lower reproductive tract (vaginal and cervical samples)

Abundance in Group 1: increased abundance in Serous ovarian cancer

NCBI Quality ControlLinks
Anaerococcus senegalensis
Corynebacterium tuberculostearicum
Facklamia hominis
Anaerococcus
Facklamia
Corynebacterium

Revision editor(s): KateRasheed, WikiWorks

Experiment 23


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Ovary Animal ovary,Female gonad,Female organism genitalia gonad,Female organism genitalia gonada,Female organism reproductive system gonad,Female organism reproductive system gonada,Female reproductive system gonad,Female reproductive system gonada,Genitalia of female organism gonad,Genitalia of female organism gonada,Gonad of female organism genitalia,Gonad of female organism reproductive system,Gonad of female reproductive system,Gonad of genitalia of female organism,Gonad of reproductive system of female organism,Gonada of female organism genitalia,Gonada of female organism reproductive system,Gonada of female reproductive system,Gonada of genitalia of female organism,Gonada of reproductive system of female organism,Ovaries,Ovarium,Ovum-producing ovary,Reproductive system of female organism gonad,Reproductive system of female organism gonada,Ovary,ovary


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 10

Description: Differential abundance of taxa between Benign and Serous ovarian cancer patients, gotten from ovaries

Abundance in Group 1: decreased abundance in Serous ovarian cancer

NCBI Quality ControlLinks
Microbacterium lacus
Actinomycetota

Revision editor(s): KateRasheed, WikiWorks

Experiment 24


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Peritoneal fluid Peritoneal fluid,peritoneal fluid


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 10

Description: Differential abundance of taxa between Benign and Serous ovarian cancer patients, gotten from Ascites/Peritoneal Fluid

Abundance in Group 1: increased abundance in Serous ovarian cancer

NCBI Quality ControlLinks
Methylorubrum extorquens
Methylobacterium

Revision editor(s): KateRasheed, WikiWorks

Experiment 25


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Urine Urine,urine
Group 1 name Corresponds to the case (exposed) group for case-control studies
Other histologies
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Other histologies refers to patients with mucinous, endometroid and clear cell.
Group 1 sample size Number of subjects in the case (exposed) group
5

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 11

Description: Differential abundance of taxa between Benign and patients with other histologies, gotten from urine.

Abundance in Group 1: increased abundance in Other histologies

NCBI Quality ControlLinks
Anaeroglobus geminatus
Dialister propionicifaciens
Dialister
Anaeroglobus

Revision editor(s): KateRasheed, WikiWorks

Experiment 26


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Fallopian tube Fallopian tubes,Female paramesonephric duct,Mammalian oviduct,Paramesonephric duct of female,Salpinges,Salpinx,Tuba uterina,Uterine tube (sensu Mammalia),Fallopian tube,fallopian tube


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 11

Description: Differential abundance of taxa between Benign and patients with other histologies, gotten from the fallopian tubes.

Abundance in Group 1: increased abundance in Other histologies

NCBI Quality ControlLinks
Lactobacillus iners AB-1
Lactobacillus

Revision editor(s): KateRasheed, WikiWorks

Experiment 27


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Vagina , Uterine cervix Distal oviductal region,Distal portion of oviduct,Vaginae,Vagina,vagina,Canalis cervicis uteri,Caudal segment of uterus,Cervical canal,Cervical canal of uterus,Cervix,Cervix of uterus,Cervix uteri,Neck of uterus,Uterine cervix,uterine cervix


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
increased
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 11

Description: Differential abundance of taxa between Benign and patients with other histologies, gotten from Lower reproductive tract (vaginal and cervical samples)

Abundance in Group 1: increased abundance in Other histologies

NCBI Quality ControlLinks
Agathobacter rectalis
Blautia sp.
Corynebacterium singulare
Corynebacterium sp.
Faecalibacterium prausnitzii
Fusicatenibacter saccharivorans
Mediterraneibacter faecis
Mobiluncus curtisii
Schaalia turicensis
uncultured Dialister sp.
Dialister
Blautia
Mobiluncus
Agathobacter
Fusicatenibacter
[Ruminococcus] torques
Faecalibacterium
Actinomyces
Corynebacterium
Actinomycetota

Revision editor(s): KateRasheed, WikiWorks

Experiment 28


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Fallopian tube Fallopian tubes,Female paramesonephric duct,Mammalian oviduct,Paramesonephric duct of female,Salpinges,Salpinx,Tuba uterina,Uterine tube (sensu Mammalia),Fallopian tube,fallopian tube
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Serous ovarian cancer
Group 0 sample size Number of subjects in the control (unexposed) group
29

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 12

Description: Differential abundance of taxa between Serous and patients with other histologies, gotten from fallopian tube

Abundance in Group 1: increased abundance in Other histologies

NCBI Quality ControlLinks
Lactobacillus iners AB-1
Lactobacillus

Revision editor(s): KateRasheed, WikiWorks

Experiment 29


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Omentum Omentum,omentum


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 12

Description: Differential abundance of taxa between Serous and patients with other histologies, gotten from omentum.

Abundance in Group 1: increased abundance in Other histologies

NCBI Quality ControlLinks
Angelakisella massiliensis
Lachnospira eligens
uncultured Bacillota bacterium

Revision editor(s): KateRasheed, WikiWorks

Experiment 30


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Urine Urine,urine


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 12

Description: Differential abundance of taxa between Benign and patients with other histologies, gotten from urine.

Abundance in Group 1: increased abundance in Other histologies

NCBI Quality ControlLinks
Anaerococcus murdochii
Anaerococcus sp. Marseille-P3915
Anaeroglobus geminatus
Dialister propionicifaciens
Fusobacterium nucleatum
Hallella bergensis
Hoylesella buccalis
Porphyromonas endodontalis
uncultured Prevotella sp.
Prevotella 6Prevotella 6
Prevotella
Anaerococcus
Fusobacterium
Porphyromonas
Dialister
Anaeroglobus

Revision editor(s): KateRasheed, WikiWorks

Experiment 31


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Peritoneal fluid Peritoneal fluid,peritoneal fluid
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Treatment outcome measurement Treatment outcome measurement,treatment outcome measurement
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Sensitive (chemotherapy sensitive OCs)
Group 1 name Corresponds to the case (exposed) group for case-control studies
Other tumor responses (refractory/resistant)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Other tumor responses refers to other responses (refractory/resistant) to tumor treatment that was gotten from patients. Refractory means recurrence while receiving the chemotherapy or within four weeks of the last dose of therapy; while resistant means recurrence from 4 weeks to 6 months after the last dose of chemotherapy
Group 0 sample size Number of subjects in the control (unexposed) group
21
Group 1 sample size Number of subjects in the case (exposed) group
4

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/17

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 13

Description: Differential abundance of taxa between Sensitive and other tumor responses, gotten from Ascites/peritoneal fluid

Abundance in Group 1: increased abundance in Other tumor responses (refractory/resistant)

NCBI Quality ControlLinks
Anaerococcus tetradius
Anaerococcus

Revision editor(s): KateRasheed, WikiWorks

Experiment 32


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/18

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
No event - 2 years post-diagnosis
Group 1 name Corresponds to the case (exposed) group for case-control studies
Patient status (Alive) - 2 years post-diagnosis
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Patient status (Alive) refers to patients that are alive after two years of diagnosis
Group 0 sample size Number of subjects in the control (unexposed) group
17
Group 1 sample size Number of subjects in the case (exposed) group
11

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/18

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 14

Description: Differential abundance of taxa between no event vs alive, gotten from Ascites/peritoneal fluid

Abundance in Group 1: increased abundance in Patient status (Alive) - 2 years post-diagnosis

NCBI Quality ControlLinks
Anaerococcus tetradius
Campylobacter ureolyticus
Lactobacillus gasseri
Methylobacterium radiotolerans
Peptoniphilus harei
Anaerococcus
Peptoniphilus
Campylobacter
Lactobacillus
Methylobacterium

Revision editor(s): KateRasheed, WikiWorks

Experiment 33


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/18

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/18

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 14

Description: Differential abundance of taxa between no event vs alive, gotten from stool.

Abundance in Group 1: increased abundance in Patient status (Alive) - 2 years post-diagnosis

NCBI Quality ControlLinks
Amedibacterium intestinale
Bacteroides ovatus
Blautia pseudococcoides
Clostridium
Dialister invisus
Intestinimonas sp.
Lachnoclostridium sp.
Mediterraneibacter gnavus
Parasutterella excrementihominis
Veillonella nakazawae
Veillonella parvula
uncultured Bacteroidota bacterium
uncultured Dorea sp.
Bacteroides
Intestinimonas
Dialister
Blautia
Bacillota
Parasutterella
Faecalitalea
Veillonella
Ruminiclostridium

Revision editor(s): KateRasheed, WikiWorks

Experiment 34


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/18

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Urine Urine,urine
Group 1 name Corresponds to the case (exposed) group for case-control studies
Patient status (Dead) - 2 years post-diagnosis
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Patient status (Dead) refers to patients that are dead after two years of diagnosis
Group 1 sample size Number of subjects in the case (exposed) group
5

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
increased
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/18

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 15

Description: Differential abundance of taxa between no event vs dead, gotten from urine.

Abundance in Group 1: increased abundance in Patient status (Dead) - 2 years post-diagnosis

NCBI Quality ControlLinks
Anaerococcus vaginalis
Schaalia radingae
Anaerococcus
Actinomyces

Revision editor(s): KateRasheed, WikiWorks

Experiment 35


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/18

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces


Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/18

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 15

Description: Differential abundance of taxa between no event vs dead, gotten from stool.

Abundance in Group 1: increased abundance in Patient status (Dead) - 2 years post-diagnosis

NCBI Quality ControlLinks
Butyricicoccus faecihominis
Eisenbergiella tayi
Lacticaseibacillus paracasei
Sutterella wadsworthensis
Varibaculum cambriense
uncultured Coprococcus sp.
uncultured bacterium
Varibaculum
Coprococcus
Bacillota
Eisenbergiella
Sutterella
Lactobacillus
Butyricicoccus

Revision editor(s): KateRasheed, WikiWorks

Experiment 36


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/18

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Event - 2 years
Group 0 sample size Number of subjects in the control (unexposed) group
11

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/18

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 16

Description: Differential abundance of taxa between event vs dead, gotten from stool after two years post-diagnosis.

Abundance in Group 1: decreased abundance in Patient status (Dead) - 2 years post-diagnosis

NCBI Quality ControlLinks
Dialister invisus
Dialister

Revision editor(s): KateRasheed, WikiWorks

Experiment 37


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/18

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Vagina , Uterine cervix Distal oviductal region,Distal portion of oviduct,Vaginae,Vagina,vagina,Canalis cervicis uteri,Caudal segment of uterus,Cervical canal,Cervical canal of uterus,Cervix,Cervix of uterus,Cervix uteri,Neck of uterus,Uterine cervix,uterine cervix
Group 0 name Corresponds to the control (unexposed) group for case-control studies
No event - 4 years post-diagnosis
Group 1 name Corresponds to the case (exposed) group for case-control studies
Patient status (Alive) - 4 years post-diagnosis
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Patient status (Alive) refers to patients that are alive after four years of diagnosis
Group 0 sample size Number of subjects in the control (unexposed) group
4
Group 1 sample size Number of subjects in the case (exposed) group
6

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/18

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 17

Description: Differential abundance of taxa between no event vs alive after four years post-diagnosis, gotten from the Lower reproductive tract (vagina and cervix).

Abundance in Group 1: increased abundance in Patient status (Alive) - 4 years post-diagnosis

NCBI Quality ControlLinks
Actinomyces
Actinomyces urogenitalis
Actinomycetota
Adlercreutzia
Adlercreutzia equolifaciens
Agathobacter
Agathobacter rectalis
Agathobaculum butyriciproducens
Anaerobutyricum hallii
Anaerobutyricum soehngenii
Anaerococcus
Anaerococcus octavius
Anaeroglobus
Anaeroglobus geminatus
Bacillota
Bacteroides
Bacteroides ovatus
Bacteroides thetaiotaomicron
Bacteroides uniformis
Blautia
Blautia faecicola
Blautia sp.
Butyricicoccus
Campylobacter
Campylobacter ureolyticus
Clostridiales bacterium S5-A14a
Corynebacterium
Corynebacterium sp.
Dialister
Dialister invisus
Dialister propionicifaciens
Eubacterium difficile
Eubacterium xylanophilum
Ezakiella
Ezakiella coagulans
Faecalibacterium
Faecalibacterium prausnitzii
Fenollaria massiliensis
Fusicatenibacter
Fusicatenibacter saccharivorans
Fusobacterium
Fusobacterium nucleatum
Hoylesella buccalis
Hoylesella timonensis
Lachnoclostridium
Lachnoclostridium sp.
Lactobacillus
Lactobacillus iners AB-1
Mogibacterium
Odoribacter
Odoribacter splanchnicus
Olegusella massiliensis
Parabacteroides
Parabacteroides distasonis
Peptococcus
Peptococcus niger
Peptococcus sp.
Peptoniphilus
Peptoniphilus koenoeneniae
Peptoniphilus lacydonensis
Peptostreptococcus
Peptostreptococcus anaerobius
Porphyromonas
Porphyromonas bennonis
Porphyromonas endodontalis
Prevotella
Pyramidobacter
Roseateles
Roseateles depolymerans
Roseburia
Roseburia faecis
Roseburia inulinivorans
Ruminiclostridium
Ruminococcus gauvreauii
Varibaculum
Varibaculum cambriense
[Clostridium] leptum
uncultured Actinomycetales bacterium
uncultured Anaerovorax sp.
uncultured Dialister sp.
uncultured Eubacterium sp.
uncultured Mogibacterium sp.
uncultured Peptococcus sp.
uncultured Peptoniphilus sp.
uncultured Prevotella sp.
Veillonellaceae bacterium DNF00626
Rarimicrobium hominis
Prevotella 6Prevotella 6

Revision editor(s): KateRasheed, WikiWorks

Experiment 38


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/18

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
Patient status (Dead) - 4 years post-diagnosis
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Patient status (Dead) refers to patients that are dead after four years of diagnosis
Group 1 sample size Number of subjects in the case (exposed) group
11

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/18

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 18

Description: Differential abundance of taxa between no event vs dead after four years post-diagnosis, gotten from the Lower reproductive tract (vagina and cervix).

Abundance in Group 1: decreased abundance in Patient status (Dead) - 4 years post-diagnosis

NCBI Quality ControlLinks
Hoylesella buccalis
Prevotella

Revision editor(s): KateRasheed, WikiWorks

Experiment 39


Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/18

Curator: KateRasheed

Revision editor(s): WikiWorks, KateRasheed

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Event - 4 years post-diagnosis
Group 0 sample size Number of subjects in the control (unexposed) group
6

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-1-10

Curated date: 2024/12/18

Curator: KateRasheed

Revision editor(s): KateRasheed, WikiWorks

Source: Supplementary Table 1, Supplementary Table 19

Description: Differential abundance of taxa between event vs dead after four years post-diagnosis, gotten from the Lower reproductive tract (vagina and cervix).

Abundance in Group 1: decreased abundance in Patient status (Dead) - 4 years post-diagnosis

NCBI Quality ControlLinks
Hoylesella buccalis
Prevotella

Revision editor(s): KateRasheed, WikiWorks