Changes in the vaginal microbiome during pregnancy and the postpartum period in South African women: a longitudinal study/Experiment 10
From BugSigDB
Subjects
- Location of subjects
- South Africa
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Vagina Distal oviductal region,Distal portion of oviduct,Vaginae,Vagina,vagina
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Trichomonas vaginitis Leukorrhoea vaginalis - trichomonal,Trichomonal leukorrhoea,Trichomonal vaginitis &/or vulvovaginitis,Trichomonal vaginitis (disorder),Trichomonal vulvovaginitis,Trichomonal vulvovaginitis (disorder),Trichomonas vaginalis caused disease of genitourinary system,Trichomonas vaginalis disease of genitourinary system,Trichomonas vaginalis trichomoniasis,Trichomonas Vaginitis,Trichomonas vaginitis,Trichomonas vaginitis urogenital infection,urogenital infection by Trichomonas vaginalis,urogenital infection caused by Trichomonas vaginalis,urogenital Trichomonas,urogenital trichomoniasis,vaginal trichomoniasis (disorder),trichomonas vaginitis
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Pregnant women ≥ 18 years of age without Trichomonas vaginalis (TV) infection at Visit A
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Pregnant women ≥ 18 years of age with Trichomonas vaginalis (TV) infection at Visit A
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Pregnant women ≥ 18 years of age with Trichomonas vaginalis (TV) infection diagnosis whose mean gestational age at Visit A (first ANC visit) was 18.6 weeks (SD 6.3), with a range of 6–30 weeks.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 204
- Group 1 sample size Number of subjects in the case (exposed) group
- 38
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- raw counts
- Statistical test
- Zero-Inflated Negative Binomial Regression
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Signature 1
Source: Supplement S10 d
Description: Differential abundance testing of vaginal microbial species in women with and without Trichomonas vaginalis (TV) infection diagnosis (zero-inflated negative binomial model)
Abundance in Group 1: increased abundance in Pregnant women ≥ 18 years of age with Trichomonas vaginalis (TV) infection at Visit A
| NCBI | Quality Control | Links |
|---|---|---|
| Metamycoplasma hominis |
Revision editor(s): Tosin
