Changes in the vaginal microbiome during pregnancy and the postpartum period in South African women: a longitudinal study/Experiment 5
From BugSigDB
Subjects
- Location of subjects
- South Africa
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Vagina Distal oviductal region,Distal portion of oviduct,Vaginae,Vagina,vagina
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Sexually transmitted disease disease (VD), venereal,disease, sexually Transmitted,disease, venereal,diseases, sexually Transmitted,diseases, venereal,infection, sexually Transmitted,infections, sexually Transmitted,sexually transmitted disease,sexually Transmitted disorder,sexually Transmitted infection,sexually Transmitted infections,STD,STDs,STI,STIs,Transmitted infection, sexually,Transmitted infections, sexually,VD,VD, venereal disease,venereal disease,venereal disease (VD),venereal diseases,Sexually transmitted disease
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Pregnant women ≥ 18 years of age without any sexually transmitted infection (STI) at Postpartum (PPt) visit
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Pregnant women ≥ 18 years of age with any sexually transmitted infection (STI) at Postpartum (PPt) visit.
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Pregnant women ≥ 18 years of age with any sexually transmitted infection (STI) diagnosis whose mean gestational age at the postpartum visit was 17 days after delivery.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 162
- Group 1 sample size Number of subjects in the case (exposed) group
- 80
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- raw counts
- Statistical test
- Zero-Inflated Negative Binomial Regression
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Signature 1
Source: Supplement S10 a
Description: Differential abundance testing of vaginal microbial species in women with and without any sexually transmitted infection, STI diagnosis (zero-inflated negative binomial model)
Abundance in Group 1: increased abundance in Pregnant women ≥ 18 years of age with any sexually transmitted infection (STI) at Postpartum (PPt) visit.
| NCBI | Quality Control | Links |
|---|---|---|
| Prevotella sp. |
Revision editor(s): Tosin
