Changes in the vaginal microbiome during pregnancy and the postpartum period in South African women: a longitudinal study/Experiment 8
From BugSigDB
Subjects
- Location of subjects
- South Africa
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Vagina Distal oviductal region,Distal portion of oviduct,Vaginae,Vagina,vagina
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Chlamydia trachomatis infectious disease chlamydia,Chlamydia Infections,Chlamydia trachomatis caused disease or disorder,Chlamydia trachomatis disease or disorder,Chlamydia trachomatis infectious disease,chlamydia trachomatis infectious disease,chlamydial disease,Chlamydial Infection,Chlamydial infection
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Pregnant women ≥ 18 years of age without Chlamydia trachomatis (CT) infection at postpartum (PPt) visit.
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Pregnant women ≥ 18 years of age with Chlamydia trachomatis (CT) infection at postpartum (PPt) visit
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Pregnant women ≥ 18 years of age with Chlamydia trachomatis (CT) infection diagnosis whose mean gestational age at the postpartum visit was 17 days after delivery.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 190
- Group 1 sample size Number of subjects in the case (exposed) group
- 52
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- raw counts
- Statistical test
- Zero-Inflated Negative Binomial Regression
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Signature 1
Source: Supplement S10 b
Description: Differential abundance testing of vaginal microbial species in women with and without Chlamydia trachomatis (CT) infection diagnosis (zero-inflated negative binomial model)
Abundance in Group 1: increased abundance in Pregnant women ≥ 18 years of age with Chlamydia trachomatis (CT) infection at postpartum (PPt) visit
| NCBI | Quality Control | Links |
|---|---|---|
| Prevotella sp. |
Revision editor(s): Tosin
