Association of cigarette smoking with oral bacterial microbiota and cardiometabolic health in Chinese adults/Experiment 1
From BugSigDB
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Saliva Sailva normalis,Saliva atomaris,Saliva molecularis,Salivary gland secretion,Saliva,saliva
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Smoking status measurement Smoking status measurement,smoking status measurement
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-smokers
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Smokers
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants who smoked one or more cigarettes every three days for at least 6 consecutive months were classified as smokers.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 476
- Group 1 sample size Number of subjects in the case (exposed) group
- 111
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Alpha Diversity
- Pielou Quantifies how equal the community is numerically
- increased
- Shannon Estimator of species richness and species evenness: more weight on species richness
- increased
- Richness Number of species
- increased
- Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
- increased
Signature 1
Source: Table S1, Figure 1B, Table S3
Description: Phylum and genus level composition of the oral microbiome by cigarette smoking status between non-smokers and smokers group.
Abundance in Group 1: increased abundance in Smokers
| NCBI | Quality Control | Links |
|---|---|---|
| Actinomyces | ||
| Actinomycetota | ||
| Anaeroglobus | ||
| Atopobium | ||
| Bacillota | ||
| Dialister | ||
| Howardella | ||
| Megasphaera | ||
| Rothia | ||
| Romboutsia |
Revision editor(s): Tosin
Signature 2
Source: Table S1, Figure 1B, Table S3
Description: Phylum and genus level composition of the oral microbiome by cigarette smoking status between non-smokers and smokers group.
Abundance in Group 1: decreased abundance in Smokers
| NCBI | Quality Control | Links |
|---|---|---|
| Pseudomonadota | ||
| Johnsonella |
Revision editor(s): Tosin
