Associations of the Gut Microbiome With Treatment Resistance in Schizophrenia/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2024-7-16
Curated date: 2024/06/27
Curator: Jacob A. De Jesus
Revision editor(s): Jacob A. De Jesus, Scholastica, WikiWorks
Subjects
- Location of subjects
- Australia
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Schizophrenia [X]Schizophrenia, unspecified,[X]Schizophrenia, unspecified (disorder),Dementia Praecox,Disorder, Schizophrenic,Disorders, Schizophrenic,Other specified types of schizophrenia,Other specified types of schizophrenia, chronic state,Other specified types of schizophrenia, chronic state with acute exacerbation,Other specified types of schizophrenia, in remission,Other specified types of schizophrenia, subchronic state,Other specified types of schizophrenia, subchronic state with acute exacerbation,Other specified types of schizophrenia, unspecified state,SCHIZO NEC-CHR/EXACERB,SCHIZO NEC-SUBCHR/EXACER,SCHIZO NOS-CHR/EXACERB,SCHIZO NOS-SUBCHR/EXACER,schizoaffective disorder,schizophrenia,schizophrenia (disease),Schizophrenia (disorder),SCHIZOPHRENIA NEC-CHR,SCHIZOPHRENIA NEC-REMISS,SCHIZOPHRENIA NEC-SUBCHR,SCHIZOPHRENIA NEC-UNSPEC,Schizophrenia NOS,Schizophrenia NOS (disorder),SCHIZOPHRENIA NOS-UNSPEC,schizophrenia with or without an affective disorder,Schizophrenia, NOS,schizophrenia-1,Schizophrenias,SCHIZOPHRENIC DIS,Schizophrenic Disorder,Schizophrenic Disorders,Schizophrenic disorders (disorder),SCZD,Unspecified schizophrenia,Unspecified schizophrenia (disorder),Unspecified schizophrenia, chronic state with acute exacerbation,Unspecified schizophrenia, subchronic state with acute exacerbation,Unspecified schizophrenia, unspecified state,Schizophrenia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- control individuals without a psychiatric diagnosis (past or present)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- SCZ: individuals with a psychiatric diagnosis of schizophrenia
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with a schizophrenia diagnosis categorized as follows: 1. AAP: individuals with treatment-responsive schizophrenia taking atypical antipsychotics (not clozapine) with a total Positive and Negative Symptom Scale (PANSS) score of 60 or low. 2. CR: individuals with treatment-resistant schizophrenia who were clozapine responsive total PANSS score ≤60). 3. CNR: individuals with treatment-resistant schizophrenia who were clozapine nonresponsive (total PANSS score >60).
- Group 0 sample size Number of subjects in the control (unexposed) group
- 25
- Group 1 sample size Number of subjects in the case (exposed) group
- 72
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 2 months
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- centered log-ratio
- Statistical test
- ANCOM
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- .05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Matched on Factors on which subjects have been matched on in a case-control study
- age, body mass index, sex
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, body mass index, sex
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- unchanged
- Richness Number of species
- decreased
Signature 4
Reviewed Marked as Reviewed by Svetlana up on 2024-7-16
Curated date: 2024/06/29
Curator: Jacob A. De Jesus
Revision editor(s): Jacob A. De Jesus, WikiWorks
Source: Figure 3
Description: Differentially abundant species identified for control individuals and SCZ group comparisons. Analyses were performed using ANCOM-BC, adjusting for age, sex, and body mass index.
Abundance in Group 1: increased abundance in SCZ: individuals with a psychiatric diagnosis of schizophrenia
Revision editor(s): Jacob A. De Jesus, WikiWorks
Signature 5
Reviewed Marked as Reviewed by Svetlana up on 2024-7-16
Curated date: 2024/06/29
Curator: Jacob A. De Jesus
Revision editor(s): Jacob A. De Jesus, WikiWorks
Source: Figure 3
Description: Differentially abundant species identified for control individuals and SCZ group comparisons. Analyses were performed using ANCOM-BC, adjusting for age, sex, and body mass index.
Abundance in Group 1: decreased abundance in SCZ: individuals with a psychiatric diagnosis of schizophrenia
| NCBI | Quality Control | Links |
|---|---|---|
| Romboutsia timonensis | ||
| ER4 sp000765235ER4 sp000765235 | ||
| KLE1615 sp900066985KLE1615 sp900066985 | ||
| Oscillibacter sp001916835Oscillibacter sp001916835 |
Revision editor(s): Jacob A. De Jesus, WikiWorks
