Associations of the Gut Microbiome With Treatment Resistance in Schizophrenia/Experiment 3
Curated date: 2024/06/29
Curator: Jacob A. De Jesus
Revision editor(s): Jacob A. De Jesus, Scholastica, WikiWorks
Subjects
- Location of subjects
- Australia
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Treatment refractory schizophrenia refractory schizophrenia,treatment resistant schizophrenia,treatment-refractory schizophrenia,TRS,Treatment refractory schizophrenia,treatment refractory schizophrenia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- AAP: individuals with treatment-responsive schizophrenia taking atypical antipsychotics (not clozapine)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- TRS: individuals with treatment-resistant schizophrenia taking clozapine
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with treatment-resistant schizophrenia categorized as follows: 1. CR: individuals with treatment-resistant schizophrenia who were clozapine responsive total PANSS score ≤60). 2. CNR: individuals with treatment-resistant schizophrenia who were clozapine nonresponsive (total PANSS score >60).
- Group 0 sample size Number of subjects in the control (unexposed) group
- 24
- Group 1 sample size Number of subjects in the case (exposed) group
- 48
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 2 months
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- centered log-ratio
- Statistical test
- ANCOM
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- .05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Matched on Factors on which subjects have been matched on in a case-control study
- age, body mass index, sex
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, body mass index, sex
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- unchanged
- Richness Number of species
- unchanged
Signature 1
Curated date: 2024/07/01
Curator: Jacob A. De Jesus
Revision editor(s): Jacob A. De Jesus, WikiWorks
Source: Figure 3
Description: Differentially abundant species identified for AAP and TRS group comparisons. Analyses were performed using ANCOM-BC, adjusting for age, sex, and body mass index.
Abundance in Group 1: increased abundance in TRS: individuals with treatment-resistant schizophrenia taking clozapine
Revision editor(s): Jacob A. De Jesus, WikiWorks
Signature 2
Curated date: 2024/07/01
Curator: Jacob A. De Jesus
Revision editor(s): Jacob A. De Jesus, WikiWorks
Source: Figure 3
Description: Differentially abundant species identified for AAP and TRS group comparisons. Analyses were performed using ANCOM-BC, adjusting for age, sex, and body mass index.
Abundance in Group 1: decreased abundance in TRS: individuals with treatment-resistant schizophrenia taking clozapine
| NCBI | Quality Control | Links |
|---|---|---|
| Faecalibacterium MIC7145Faecalibacterium MIC7145 | ||
| Faecalibacterium prausnitzii DFaecalibacterium prausnitzii D |
Revision editor(s): Jacob A. De Jesus, WikiWorks
