Characteristics of Oral-Gut Microbiota in Model Rats with CUMS-Induced Depression/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-4-7
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Rattus norvegicus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Oral cavity Bucca,Buccal cavity,Cavity of mouth,Oral cavity,oral cavity
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Major depressive disorder major depression,major depressive disorder,recurrent major depression,single major depressive episode,unipolar depression,Major depressive disorder
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Control group (Rats without CUMS - induced depression
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- CUMS group (Rats with chronic unpredictable mild stress- induced depression)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- This group consisted of rats subjected to a Chronic Unpredictable Mild Stress (CUMS) protocol to induce depressive-like symptoms.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 10
- Group 1 sample size Number of subjects in the case (exposed) group
- 10
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 3
Alpha Diversity
- Chao1 Abundance-based estimator of species richness
- increased
- Richness Number of species
- increased
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-4-7
Source: Figure 5A
Description: Comparison of oral microbiota composition between between CUMS-induced depressed rats and control rats.
Abundance in Group 1: increased abundance in CUMS group (Rats with chronic unpredictable mild stress- induced depression)
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-4-7
Source: Figure 5A
Description: Comparison of oral microbiota composition between CUMS-induced depressed rats and control rats
Abundance in Group 1: decreased abundance in CUMS group (Rats with chronic unpredictable mild stress- induced depression)
| NCBI | Quality Control | Links |
|---|---|---|
| Actinomycetales | ||
| Actinomycetes | ||
| Actinomycetota | ||
| Facklamia | ||
| Micrococcaceae | ||
| Paracoccus | ||
| Rhodobacterales | ||
| Rothia | ||
| Stenotrophomonas | ||
| Vibrio | ||
| Vibrionaceae | ||
| Vibrionales | ||
| Paracoccaceae |
