Maternal smoking during pregnancy increases the risk of gut microbiome-associated childhood overweight and obesity/Experiment 2
Curated date: 2024/04/22
Curator: Omojokunoluwatomisin
Revision editor(s): Omojokunoluwatomisin, Scholastica, WikiWorks
Subjects
- Location of subjects
- Canada
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Smoking behaviour measurement Smoking behaviour measurement,smoking behaviour measurement
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Late infants (12months) with maternal history of 'NO' 'smoking
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Late infants (12months) with maternal history of 'YES' 'smoking
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Infants (12 months old) whose mothers quit smoking during pregnancy, reduced the number of cigarettes, or had the same number of cigarettes (as before conception) during pregnancy.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 1458
- Group 1 sample size Number of subjects in the case (exposed) group
- 134
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- increased
- Chao1 Abundance-based estimator of species richness
- increased
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- increased
- Richness Number of species
- increased
- Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
- increased
Signature 1
Curated date: 2024/04/22
Curator: Omojokunoluwatomisin
Revision editor(s): WikiWorks, MyleeeA, Scholastica, Omojokunoluwatomisin
Source: Figure 2B, Supplementary Table S8
Description: Differentially abundant taxa identified by LEfSe in smoke exposed versus non-smoke exposed late infants (12 months old)
Abundance in Group 1: increased abundance in Late infants (12months) with maternal history of 'YES' 'smoking
Revision editor(s): WikiWorks, MyleeeA, Scholastica, Omojokunoluwatomisin
Signature 2
Curated date: 2024/04/22
Curator: Omojokunoluwatomisin
Revision editor(s): Omojokunoluwatomisin, Scholastica, WikiWorks
Source: Figure 2B, Supplementary Table S8
Description: Differentially abundant taxa identified by LEfSe in smoke exposed versus non-smoke exposed late infants (12 months old)
Abundance in Group 1: decreased abundance in Late infants (12months) with maternal history of 'YES' 'smoking
| NCBI | Quality Control | Links |
|---|---|---|
| Haemophilus | ||
| Lachnospira | ||
| Pasteurellaceae | ||
| Pasteurellales | ||
| Selenomonadales | ||
| Veillonella | ||
| Veillonellaceae |
Revision editor(s): Omojokunoluwatomisin, Scholastica, WikiWorks
