Gastrointestinal Dysmotility Predisposes to Colitis through Regulation of Gut Microbial Composition and Linoleic Acid Metabolism/Experiment 4
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-4-24
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Mus musculus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Response to transplant Response to transplant,response to transplant
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy controls - Fecal Microbiota Transplantation (HC-FMT)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Chronic Constipation - Fecal Microbiota Transplantation (CC-FMT)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Fecal microbiota transplant (FMT), recipient mice were pre-treated with a cocktail of antibiotics (ABX) in drinking water for 2 weeks. Mice were administered filtered donor fecal homogenate by oral gavage (300 μl per mouse) one day after ABX treatment every other day over a period of 10 days.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 6
- Group 1 sample size Number of subjects in the case (exposed) group
- 6
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- T-Test
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-4-24
Source: Figure 8F
Description: Differences in microbial taxa significant between Chronic Constipation - Fecal Microbiota Transplantation (CC-FMT) and Healthy controls - Fecal Microbiota Transplantation (HC-FMT).
Abundance in Group 1: increased abundance in Chronic Constipation - Fecal Microbiota Transplantation (CC-FMT)
| NCBI | Quality Control | Links |
|---|---|---|
| Akkermansia muciniphila |
Revision editor(s): MyleeeA
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-4-24
Source: Figure 8F
Description: Differences in microbial taxa significant between Chronic Constipation - Fecal Microbiota Transplantation (CC-FMT) and Healthy controls - Fecal Microbiota Transplantation (HC-FMT).
Abundance in Group 1: decreased abundance in Chronic Constipation - Fecal Microbiota Transplantation (CC-FMT)
| NCBI | Quality Control | Links |
|---|---|---|
| Lactobacillus |
Revision editor(s): MyleeeA
