Oral and gut microbial profiling in periodontitis and Parkinson's disease

Study information

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Reviewed Marked as Reviewed by Svetlana up on 2024-11-20

study design

cross-sectional observational, not case-control

Citation

PMID PubMed identifier for scientific articles.

38528960

DOI Digital object identifier for electronic documents.

https://doi.org/10.1080/20002297.2024.2331264

URI

https://www.tandfonline.com/doi/full/10.1080/20002297.2024.2331264#

Authors

Yay E, Yilmaz M, Toygar H, Balci N, Alvarez Rivas C, Bolluk Kılıç B, Zirh A, Paster BJ, Kantarci A

Journal

Journal of oral microbiology

Year

2024

Keywords:

Parkinson’s disease, Periodontitis, microbiome, next-generation sequencing, pathogenesis

OBJECTIVES: We tested the hypothesis that Parkinson's disease (PA) alters the periodontitis-associated oral microbiome. METHOD: Patients with periodontitis with Parkinson's disease (PA+P) and without PA (P) and systemically and periodontally healthy individuals (HC) were enrolled. Clinical, periodontal and neurological parameters were recorded. The severity of PA motor functions was measured. Unstimulated saliva samples and stool samples were collected. Next-generation sequencing of 16S ribosomal RNA (V1-V3 regions) was performed. RESULTS: PA patients had mild-to-moderate motor dysfunction and comparable plaque scores as those without, indicating that oral hygiene was efficient in the PA+P group. In saliva, there were statistically significant differences in beta diversity between HC and PA+P (p = 0.001), HC and P (p = 0.001), and P and PA+P (p = 0.028). The microbial profiles of saliva and fecal samples were distinct. Mycoplasma faucium, Tannerella forsythia, Parvimonas micra, and Saccharibacteria (TM7) were increased in P; Prevotella pallens, Prevotella melaninogenica, Neisseria multispecies were more abundant in PA+P group, Ruthenibacterium lactatiformans, Dialister succinatiphilus, Butyrivibrio crossotus and Alloprevotella tannerae were detected in fecal samples in P groups compared to healthy controls. CONCLUSIONS: No significant differences were detected between Parkinson's and non-Parkinson's gut microbiomes, suggesting that Parkinson's disease modifies the oral microbiome in periodontitis subjects independent of the gut microbiome.

Experiment 1

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Curated date: 2024/11/01

Curator: Aleru Divine

Revision editor(s): WikiWorks, Aleru Divine

Subjects

Location of subjects

Turkey

Host species Species from which microbiome was sampled. Contact us to have more species added.

Homo sapiens

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology

Saliva Sailva normalis,Saliva atomaris,Saliva molecularis,Salivary gland secretion,Saliva,saliva

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Periodontitis chronic pericementitis,inflammation of periodontium,Pericementitides,Pericementitis,Periodontitides,periodontitis,Periodontitis (disorder),Periodontitis, NOS,periodontium inflammation,periodontosis,Periodontitis

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Healthy controls (HC)

Group 1 name Corresponds to the case (exposed) group for case-control studies

Periodontitis group (P)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Participants in this group were diagnosed with Stage III, Grade B periodontitis.

Group 0 sample size Number of subjects in the control (unexposed) group

17

Group 1 sample size Number of subjects in the case (exposed) group

18

Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)

3 months

Lab analysis

Sequencing type

16S

16S variable region One or more hypervariable region(s) of the bacterial 16S gene

V1-V3

Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance

Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).

centered log-ratio

Statistical test

ANCOM

Significance threshold p-value or FDR threshold used for differential abundance testing (if any)

0.05

MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?

No

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness

unchanged

Simpson Estimator of species richness and species evenness: more weight on species evenness

unchanged

Richness Number of species

unchanged

Signature 1

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Curator: Aleru Divine

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Source: Figure 4 and Figure 6

Description: Differential abundance in the oral microbiome profiles of the healthy control, Parkinson’s and non-Parkinson’s groups.

Abundance in Group 1: increased abundance in Periodontitis group (P)

NCBI	Quality Control	Links
Metamycoplasma faucium
Parvimonas micra
TM7 phylum sp. oral taxon 346
TM7 phylum sp. oral taxon 349
TM7 phylum sp. oral taxon 355
TM7 phylum sp. oral taxon 356
Tannerella forsythia

Revision editor(s): Aleru Divine, WikiWorks

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Source: Figure 4 and Figure 6

Description: Differential abundance in the oral microbiome profiles of the healthy control, Parkinson’s and non-Parkinson’s groups.

Abundance in Group 1: decreased abundance in Periodontitis group (P)

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Gemella sanguinis
Prevotella melaninogenica
Prevotella pallens
Prevotellaceae bacterium
Rothia dentocariosa
Neisseria sp.

Revision editor(s): Aleru Divine, WikiWorks

Experiment 2

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Curated date: 2024/11/01

Curator: Aleru Divine

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Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies

Parkinson's disease + Periodontitis group (PA + P)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Participants in this group had Parkinson's disease and were also diagnosed with Stage III, Grade B periodontitis.

Group 1 sample size Number of subjects in the case (exposed) group

16

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness

increased

Simpson Estimator of species richness and species evenness: more weight on species evenness

increased

Richness Number of species

increased

Signature 1

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Curated date: 2024/11/02

Curator: Aleru Divine

Revision editor(s): Aleru Divine, WikiWorks

Source: Figure 4 and Figure 6

Description: Differential abundance in the oral microbiome profiles of the healthy control, Parkinson’s and non-Parkinson’s groups.

Abundance in Group 1: increased abundance in Parkinson's disease + Periodontitis group (PA + P)

NCBI	Quality Control	Links
Parvimonas micra
Prevotellaceae bacterium
Neisseria sp.
Metamycoplasma faucium
Tannerella forsythia
TM7 phylum sp. oral taxon 346
TM7 phylum sp. oral taxon 349
TM7 phylum sp. oral taxon 355
TM7 phylum sp. oral taxon 356

Revision editor(s): Aleru Divine, WikiWorks

Signature 2

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Source: Figure 4 and Figure 6

Description: Differential abundance in the oral microbiome profiles of the healthy control, Parkinson’s and non-Parkinson’s groups.

Abundance in Group 1: decreased abundance in Parkinson's disease + Periodontitis group (PA + P)

NCBI	Quality Control	Links
Rothia dentocariosa
Prevotella pallens
Gemella sanguinis
Prevotella melaninogenica

Revision editor(s): Aleru Divine, WikiWorks

Experiment 4

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Curated date: 2024/11/04

Curator: MyleeeA

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Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology

Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces

Group 1 name Corresponds to the case (exposed) group for case-control studies

Periodontitis group (P)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Participants in this group were diagnosed with Stage III, Grade B periodontitis.

Group 1 sample size Number of subjects in the case (exposed) group

18

Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)

3 Months

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness

unchanged

Simpson Estimator of species richness and species evenness: more weight on species evenness

unchanged

Richness Number of species

unchanged

Signature 1

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Curated date: 2024/11/04

Curator: MyleeeA

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Source: Figure 7A

Description: Differential abundance in the oral microbiome profiles of the Healthy controls and Periodontitis groups.

Abundance in Group 1: increased abundance in Periodontitis group (P)

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Ruthenibacterium lactatiformans
Eshraghiella crossota
Alloprevotella tannerae
Dialister succinatiphilus

Revision editor(s): MyleeeA, WikiWorks

Signature 2

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Source: Figure 7A

Description: Differential abundance in the oral microbiome profiles of the Healthy controls and Periodontitis groups.

Abundance in Group 1: decreased abundance in Periodontitis group (P)

NCBI	Quality Control	Links
Parabacteroides distasonis

Revision editor(s): MyleeeA, WikiWorks

Experiment 5

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Curated date: 2024/11/04

Curator: MyleeeA

Revision editor(s): MyleeeA, Aleru Divine, WikiWorks

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies

Parkinson's disease + Periodontitis group (PA + P)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Participants in this group had Parkinson's disease and were also diagnosed with Stage III, Grade B periodontitis.

Group 1 sample size Number of subjects in the case (exposed) group

16

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness

increased

Simpson Estimator of species richness and species evenness: more weight on species evenness

increased

Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample

increased

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Source: Figure 7A

Description: Differential abundance in the oral microbiome profiles of the Healthy controls and Parkinson's disease + Periodontitis group (PA + P).

Abundance in Group 1: increased abundance in Parkinson's disease + Periodontitis group (PA + P)

NCBI	Quality Control	Links
Eshraghiella crossota
Alloprevotella tannerae

Revision editor(s): MyleeeA, WikiWorks

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Source: Figure 7A

Description: Differential abundance in the oral microbiome profiles of the Healthy controls and Parkinson's disease + Periodontitis group (PA + P).

Abundance in Group 1: decreased abundance in Parkinson's disease + Periodontitis group (PA + P)

NCBI	Quality Control	Links
Parabacteroides distasonis

Revision editor(s): MyleeeA, WikiWorks

Experiment 6

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Curated date: 2024/11/04

Curator: MyleeeA

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Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Periodontitis group (P)

Group 0 sample size Number of subjects in the control (unexposed) group

18

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness

unchanged

Simpson Estimator of species richness and species evenness: more weight on species evenness

unchanged

Richness Number of species

unchanged

Signature 1

EditHistoryDelete

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Reviewed Marked as Reviewed by Svetlana up on 2024-11-20

Curated date: 2024/11/04

Curator: MyleeeA

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Source: Figure 7A

Description: Differential abundance in the oral microbiome profiles of the Periodontitis and Parkinson's disease + Periodontitis group (PA + P).

Abundance in Group 1: increased abundance in Parkinson's disease + Periodontitis group (PA + P)

NCBI	Quality Control	Links
Ruthenibacterium lactatiformans
Eshraghiella crossota
Alloprevotella tannerae

Revision editor(s): MyleeeA, WikiWorks

Signature 2

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Source: Figure 7A

Description: Differential abundance in the oral microbiome profiles of the Periodontitis and Parkinson's disease + Periodontitis group (PA + P).

Abundance in Group 1: decreased abundance in Parkinson's disease + Periodontitis group (PA + P)

NCBI	Quality Control	Links
Ruthenibacterium lactatiformans

Revision editor(s): MyleeeA, WikiWorks

Experiment 7

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Curated date: 2024/11/05

Curator: Aleru Divine

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Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology

Saliva , Feces Sailva normalis,Saliva atomaris,Saliva molecularis,Salivary gland secretion,Saliva,saliva,Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Sampling site Sampling site,sampling site

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Healthy controls (Feces)

Group 1 name Corresponds to the case (exposed) group for case-control studies

Healthy controls (Saliva)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Saliva samples collected from healthy control participants.

Group 0 sample size Number of subjects in the control (unexposed) group

17

Group 1 sample size Number of subjects in the case (exposed) group

17

Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)

3 months

Lab analysis

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).

relative abundances

Statistical test

LEfSe

LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool

2.0

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Source: Supplementary File 2a

Description: LefSe results representing significant difference in relative abundance in fecal and saliva samples from healthy controls.

Abundance in Group 1: increased abundance in Healthy controls (Saliva)

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Abiotrophia
Abiotrophia defectiva
Acidimicrobiia
Actinomycetaceae
Actinomycetales
Actinomycetota
Aerococcaceae
Bacillales
Bacilli
Bacteria
Bacteroidaceae
Bacteroidales
Bergeyella
Campylobacter
Campylobacteraceae
Campylobacterales
Candidatus Altimarinota
Candidatus Nanosynbacter sp. HMT-352
Candidatus Saccharibacteria
Capnocytophaga
Capnocytophaga leadbetteri
Cardiobacteriaceae
Cardiobacteriales
Cardiobacterium
Cardiobacterium hominis
Carnobacteriaceae
Epsilonproteobacteria
Filifactor
Filifactor alocis
Flavobacteriaceae
Flavobacteriales
Flavobacteriia
Fusobacteriaceae
Fusobacteriales
Fusobacteriia
Fusobacteriota
Fusobacterium
Gammaproteobacteria
Gemella
Gemella haemolysans
Gemellaceae
Granulicatella
Lactobacillales
Metamycoplasma faucium
Micrococcaceae
Mogibacterium
Mollicutes
Mycoplasma
Mycoplasmataceae
Mycoplasmatales
Neisseria
Neisseriaceae
Neisseriales
Oscillospiraceae
Parvimonas
Peptoniphilaceae
Peptostreptococcaceae
Peptostreptococcus stomatis
Porphyromonas
Porphyromonas endodontalis
Porphyromonas pasteri
Rothia
Rothia mucilaginosa
Schaalia
Selenomonas
Solobacterium
Solobacterium moorei
Spirochaetaceae
Spirochaetales
Spirochaetia
Spirochaetota
Staphylococcaceae
Stomatobaculum
Streptococcaceae
Streptococcus
Streptococcus lactarius
Streptococcus sanguinis
TM7 phylum sp. oral taxon 346
TM7 phylum sp. oral taxon 349
TM7 phylum sp. oral taxon 351
TM7 phylum sp. oral taxon 355
TM7 phylum sp. oral taxon 356
Tannerella
Tannerella forsythia
Tannerellaceae
Treponema
Treponema sp.
[Eubacterium] brachy
[Eubacterium] sulci
candidate division SR1 bacterium
unclassified Candidatus Altimarinota
unclassified Lachnospiraceae
S_multispecies_spp11_20S_multispecies_spp11_20
S_multispecies_spp7_2S_multispecies_spp7_2
S_multispecies_spp134_2S_multispecies_spp134_2
S_bacterium_HMT_075S_bacterium_HMT_075
G_Saccharibacteria_TM7_G_3G_Saccharibacteria_TM7_G_3
S_multispecies_spp118_2S_multispecies_spp118_2
F_multifamilyF_multifamily
G_multigenusG_multigenus
S_multispecies_spp27_2S_multispecies_spp27_2
S_multispecies_spp18_3S_multispecies_spp18_3
G_Saccharibacteria_TM7_G_5G_Saccharibacteria_TM7_G_5
S_bacterium_HMT_872S_bacterium_HMT_872
G_Grailibacteria_GN02_G_1G_Grailibacteria_GN02_G_1
G_Grailibacteria_GN02_G_2G_Grailibacteria_GN02_G_2
S_multispecies_spp113_2S_multispecies_spp113_2
S_bacterium_HMT_272S_bacterium_HMT_272
S_multispecies_spp17_4S_multispecies_spp17_4
S_bacterium_HMT_905S_bacterium_HMT_905
S_bacterium_HMT_369S_bacterium_HMT_369
S_bacterium_HMT_873S_bacterium_HMT_873
S_bacterium_HMT_500S_bacterium_HMT_500
G_Saccharibacteria_TM7_G_4G_Saccharibacteria_TM7_G_4
S_sp_HMT_097S_sp_HMT_097
G_Peptostreptococcaceae_XI_G_9G_Peptostreptococcaceae_XI_G_9
S_multispecies_spp95_4S_multispecies_spp95_4
S_multispecies_spp8_3S_multispecies_spp8_3
S_sp_Oral_Taxon_274S_sp_Oral_Taxon_274
S_bacterium_HMT_085S_bacterium_HMT_085
F_Saccharibacteria_TM7_F_2F_Saccharibacteria_TM7_F_2

Revision editor(s): Aleru Divine, WikiWorks

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Source: Supplementary File 2a

Description: LefSe results representing significant difference in relative abundance in fecal and saliva samples from healthy controls.

Abundance in Group 1: decreased abundance in Healthy controls (Saliva)

NCBI	Quality Control	Links
Abiotrophia sp.
Acutalibacter
Acutalibacter muris
Adlercreutzia
Adlercreutzia muris
Agathobacter rectalis
Agathobaculum
Agathobaculum desmolans
Akkermansia
Akkermansia muciniphila
Akkermansiaceae
Alistipes
Allofournierella
Allofournierella massiliensis
Alloprevotella
Alloprevotella rava
Alloprevotella tannerae
Alteracholeplasma parvum
Anaerobutyricum hallii
Anaeroplasmataceae
Anaeroplasmatales
Archaea
Asteroleplasma
Asteroleplasma anaerobium
Bacteroidaceae
Bacteroidales
Bacteroides
Bacteroides fragilis
Bacteroides hominis
Bacteroidia
Bacteroidota
Bifidobacteriaceae
Bifidobacteriales
Bifidobacterium
Bifidobacterium longum
Bilophila
Bilophila wadsworthia
Blautia
Blautia caccae
Blautia luti
Blautia sp.
Breznakia
Burkholderiales
Butyrivibrio
Butyrivibrio sp.
Caproiciproducens
Caproiciproducens galactitolivorans
Catenibacterium
Catenibacterium mitsuokai
Christensenella
Christensenella massiliensis
Christensenellaceae
Clostridia
Clostridiaceae
Clostridium
Clostridium sp.
Collinsella
Collinsella aerofaciens
Collinsella intestinalis
Coprococcus
Coprococcus catus
Coprococcus comes
Coprococcus eutactus
Coriobacteriaceae
Deltaproteobacteria
Desulfovibrio
Desulfovibrionaceae
Dialister
Dialister succinatiphilus
Dorea
Dorea formicigenerans
Dorea longicatena
Duncaniella
Duncaniella freteri
Duodenibacillus
Duodenibacillus massiliensis
Eggerthellaceae
Eggerthellales
Elusimicrobia
Elusimicrobiales
Elusimicrobium
Elusimicrobium minutum
Enterobacterales
Enterobacteriaceae
Enterocloster hominis (ex Hitch et al. 2024)
Erysipelotrichaceae
Erysipelotrichales
Erysipelotrichia
Eshraghiella crossota
Eubacteriaceae
Eubacteriales
Anaerovoracaceae
Eubacterium
Eubacterium coprostanoligenes
Eubacterium sp.
Faecalibacterium
Faecalibacterium prausnitzii
Faecalitalea
Faecalitalea cylindroides
Flavonifractor
Flavonifractor plautii
Fusicatenibacter
Fusicatenibacter saccharivorans
Holdemanella
Holdemanella biformis
Hoylesella oralis
Hoylesella shahii
Ihubacter
Kineothrix
Kineothrix alysoides
Lachnoclostridium
Lachnospira
Lachnospira eligens
Lachnospiraceae
Lacrimispora
Lacrimispora xylanolytica
Lactobacillaceae
Lactobacillus
Leptotrichia shahii
Leyella stercorea
Massiliprevotella
Massiliprevotella massiliensis
Mediterraneibacter
Mediterraneibacter faecis
Mediterraneibacter massiliensis
Methanobacteria
Methanobacteriaceae
Methanobacteriales
Methanobacteriota
Methanobrevibacter
Methanobrevibacter smithii
Mitsuokella
Mollicutes
Monoglobus
Monoglobus pectinilyticus
Muribaculaceae
Mycoplasmatota
Odoribacter splanchnicus
Odoribacteraceae
Oscillibacter
Oscillibacter ruminantium
Oscillibacter sp.
Oscillibacter valericigenes
Oscillospiraceae
Ovatus
Parabacteroides
Parabacteroides faecis
Parabacteroides merdae
Paraprevotella
Paraprevotella clara
Peptostreptococcaceae
Phocaeicola
Phocaeicola vulgatus
Prevotella
Prevotellaceae
Prevotellamassilia
Pseudobutyrivibrio ruminis
Rikenellaceae
Romboutsia timonensis
Roseburia
Roseburia inulinivorans
Roseburia sp.
Ruminiclostridium
Ruminococcus
Ruminococcus bromii
Ruminococcus callidus
Ruminococcus sp.
Ruthenibacterium
Ruthenibacterium lactatiformans
Segatella copri
Segatella oris
Selenomonas massiliensis
Sporobacter
Sporobacter termitidis
Streptococcus thermophilus
Subdoligranulum
Subdoligranulum variabile
Succinivibrio
Succinivibrio dextrinosolvens
Succinivibrionaceae
Sutterella
Sutterella massiliensis
Sutterellaceae
Thomasclavelia
Thomasclavelia spiroformis
Veillonella rogosae
Veillonellaceae
Verrucomicrobiaceae
Verrucomicrobiales
Verrucomicrobiota
[Clostridium] methylpentosum
[Eubacterium] siraeum
unclassified Oscillospiraceae
S_multispecies_spp51_2S_multispecies_spp51_2
S_bacterium_HMT_085_nov_90_766S_bacterium_HMT_085_nov_90_766
S_bacterium_HMT_085_nov_91_422S_bacterium_HMT_085_nov_91_422
S_multispecies_spp14_2S_multispecies_spp14_2
S_ bacterIum_HMT_085_nov_ 93_946S_ bacterIum_HMT_085_nov_ 93_946
S_multispecies_sppn2_2_nov_91_216S_multispecies_sppn2_2_nov_91_216
S_bacterium_HMT_402 _nov_90_337S_bacterium_HMT_402 _nov_90_337
S_bacterium_HMT_091_nov_93_213S_bacterium_HMT_091_nov_93_213
S_multispecies_spp26_5S_multispecies_spp26_5
S_bacterium_HMT_402 _nov_89 _038S_bacterium_HMT_402 _nov_89 _038
S_multispecies_spp12_2S_multispecies_spp12_2
G_ Peptostreptococcaceae_ XI_G_2G_ Peptostreptococcaceae_ XI_G_2
S_multispecies_sppn_2_nov_95_023S_multispecies_sppn_2_nov_95_023
S_multispecies_spp19_2S_multispecies_spp19_2
G_Ruminococcaceae_ G_2G_Ruminococcaceae_ G_2
O_multiorderO_multiorder
F_multifamilyF_multifamily
S_multispecies_spp29_2S_multispecies_spp29_2
G_Bacteroidetes_G_7G_Bacteroidetes_G_7
G_Lachnospiraceae_G_7G_Lachnospiraceae_G_7
S_bacterium_HMT_086S_bacterium_HMT_086
S_bacterium_HMT_402_nov_91_011S_bacterium_HMT_402_nov_91_011
G_multigenusG_multigenus
S_sp_str_D16_nov_89_414S_sp_str_D16_nov_89_414
S_bacterium_HMT_085_nov_92_809S_bacterium_HMT_085_nov_92_809
S_sp_HMT_040_NOV_92_918S_sp_HMT_040_NOV_92_918
S_sp_str_D13_NOV_91_323S_sp_str_D13_NOV_91_323
S_sp_str_NML04A032_nov_90_337S_sp_str_NML04A032_nov_90_337
S_multispecies_spp1_2S_multispecies_spp1_2
S_multispeciesS_multispecies
S_sp_str_D16_nov_93_243S_sp_str_D16_nov_93_243
S_bacterium_HMT_911_NOV_90_652S_bacterium_HMT_911_NOV_90_652
S_bacterium_HMT_899 _nov_93_290S_bacterium_HMT_899 _nov_93_290
S_sp_ HMT_090_nov_92_795S_sp_ HMT_090_nov_92_795
S_sp_str_D16_nov_95_495S_sp_str_D16_nov_95_495

Revision editor(s): Aleru Divine, WikiWorks

Experiment 8

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Curated date: 2024/11/05

Curator: Aleru Divine

Revision editor(s): WikiWorks, MyleeeA, Aleru Divine

Differences from previous experiment shown

Subjects

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Periodontitis chronic pericementitis,inflammation of periodontium,Pericementitides,Pericementitis,Periodontitides,periodontitis,Periodontitis (disorder),Periodontitis, NOS,periodontium inflammation,periodontosis,Periodontitis

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Periodontitis group (P) Feces

Group 1 name Corresponds to the case (exposed) group for case-control studies

Periodontitis group (P) Saliva

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Saliva samples collected from Periodontitis participants.

Group 0 sample size Number of subjects in the control (unexposed) group

18

Group 1 sample size Number of subjects in the case (exposed) group

18

Lab analysis

Statistical Analysis

Signature 1

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Curator: MyleeeA

Revision editor(s): MyleeeA, Aleru Divine, WikiWorks

Source: Supplementary File 2

Description: LefSe results representing significant difference in relative abundance in fecal and saliva samples from Periodontitis patients.

Abundance in Group 1: increased abundance in Periodontitis group (P) Saliva

NCBI	Quality Control	Links
Abiotrophia
Abiotrophia defectiva
Actinomycetaceae
Actinomycetales
Actinomycetes
Actinomycetota
Aerococcaceae
Bacillales
Bacilli
Bacteria
Bacteroidaceae
Bergeyella
Campylobacter
Campylobacteraceae
Campylobacterales
Capnocytophaga
Capnocytophaga leadbetteri
Cardiobacteriaceae
Cardiobacteriales
Cardiobacterium
Cardiobacterium hominis
Carnobacteriaceae
Epsilonproteobacteria
Filifactor
Filifactor alocis
Flavobacteriaceae
Flavobacteriales
Flavobacteriia
Fusobacteriaceae
Fusobacteriales
Fusobacteriia
Fusobacteriota
Fusobacterium
Gammaproteobacteria
Gemella
Gemella haemolysans
Gemella sanguinis
Gemellaceae
Granulicatella
Lactobacillales
Metamycoplasma faucium
Micrococcaceae
Mogibacterium
Mollicutes
Mycoplasmatales
Neisseria
Neisseriaceae
Parvimonas
Peptoniphilaceae
Peptostreptococcaceae
Peptostreptococcus
Peptostreptococcus stomatis
Porphyromonas
Porphyromonas endodontalis
Porphyromonas pasteri
Rothia
Rothia mucilaginosa
Schaalia
Selenomonas
Solobacterium moorei
Spirochaetaceae
Spirochaetales
Spirochaetia
Spirochaetota
Staphylococcaceae
Stomatobaculum
Streptococcaceae
Streptococcus
Streptococcus lactarius
Streptococcus sanguinis
Tannerella
Tannerella forsythia
Tannerellaceae
Treponema
Turicibacter sanguinis
[Eubacterium] brachy
[Eubacterium] sulci
G_Saccharibacteria_TM7_G_1G_Saccharibacteria_TM7_G_1
S_multispecies7_2S_multispecies7_2
S_multispecies_spp118_2S_multispecies_spp118_2
F_multifamilyF_multifamily
S_multispecies134_2S_multispecies134_2
S_bacteria_HMT 352S_bacteria_HMT 352
G_multigenusG_multigenus
S_multispecies_spp5_2S_multispecies_spp5_2
S_bacterium_HMT_349S_bacterium_HMT_349
G_Ruminococcaceae_G_1G_Ruminococcaceae_G_1
S_bacterium_HMT_346S_bacterium_HMT_346
S_multispecies_spp27_2S_multispecies_spp27_2
S_multispecies_spp18_3S_multispecies_spp18_3
G_Peptostreptococcaceae_XI_G_1G_Peptostreptococcaceae_XI_G_1
S_bacterium_HMT_356S_bacterium_HMT_356
G_Saccharibacteria_TM7_G_5G_Saccharibacteria_TM7_G_5
F_Saccharibacteria_TM7_F_2F_Saccharibacteria_TM7_F_2
S_bacterium_HMT_905S_bacterium_HMT_905
S_bacterium_HMT_872S_bacterium_HMT_872
S_bacterium_HMT_369S_bacterium_HMT_369
S_multispecies_spp17_4S_multispecies_spp17_4
S_bacteria_HMT_351S_bacteria_HMT_351
S_sp_HMT_322S_sp_HMT_322
G_Absconditabacteria_SR1_G_1G_Absconditabacteria_SR1_G_1
S_bacterium_HMT_500S_bacterium_HMT_500
S_multispecies_spp113_2S_multispecies_spp113_2
S_bacterium_HMT_272S_bacterium_HMT_272
G_Peptostreptococcaceae_XI_G_4G_Peptostreptococcaceae_XI_G_4
G_Lachnospiraceae_G_8G_Lachnospiraceae_G_8
G_Gracilibacteria_GN02G_Gracilibacteria_GN02
S_bacterium_HMT_346_nov_97_968S_bacterium_HMT_346_nov_97_968
S_bacterium_HMT_355S_bacterium_HMT_355
G_Saccharibacteria_TM7_G_4G_Saccharibacteria_TM7_G_4
S_sp_HMT_097S_sp_HMT_097
G_Peptostreptococcaceae_XI_G_9G_Peptostreptococcaceae_XI_G_9
G_Bacteroidaceae_G_1G_Bacteroidaceae_G_1
C_Absconditabacteria_SR1_C_1C_Absconditabacteria_SR1_C_1
F_Absconditabacteria_SR1_F_1F_Absconditabacteria_SR1_F_1
O_Absconditabacteria_SR1_O_1O_Absconditabacteria_SR1_O_1
G_Gracilibacteria_GN02_G_2G_Gracilibacteria_GN02_G_2
G_Bacteriodales_G_2G_Bacteriodales_G_2
S_bacterium_HMT_873S_bacterium_HMT_873
S_multispecies_spp95_4S_multispecies_spp95_4
F_Bacteriodales_F_2F_Bacteriodales_F_2
S_multispecies_spp8_3S_multispecies_spp8_3
S_sp_Oral_Taxon_274S_sp_Oral_Taxon_274
S_bacterium_HMT_085S_bacterium_HMT_085

Revision editor(s): MyleeeA, Aleru Divine, WikiWorks

Signature 2

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Curator: MyleeeA

Revision editor(s): MyleeeA, Aleru Divine, WikiWorks

Source: Supplementary File 2

Description: LefSe results representing significant difference in relative abundance in fecal and saliva samples from Periodontitis patients.

Abundance in Group 1: decreased abundance in Periodontitis group (P) Saliva

NCBI	Quality Control	Links
Acutalibacter
Acutalibacter muris
Adlercreutzia
Adlercreutzia muris
Aeromonadales
Agathobacter rectalis
Agathobaculum
Agathobaculum desmolans
Akkermansia
Akkermansia muciniphila
Akkermansiaceae
Alistipes
Allofournierella
Allofournierella massiliensis
Alloprevotella
Alloprevotella rava
Alloprevotella tannerae
Alteracholeplasma parvum
Anaerobutyricum hallii
Anaeroplasmataceae
Anaeroplasmatales
Archaea
Asteroleplasma
Asteroleplasma anaerobium
Bacteroidaceae
Bacteroidales
Bacteroides
Bacteroides faecis
Bacteroides fragilis
Bacteroides intestinalis
Bacteroides ovatus
Bacteroidia
Bacteroidota
Bifidobacteriaceae
Bifidobacteriales
Bifidobacterium
Bifidobacterium longum
Bilophila
Bilophila wadsworthia
Blautia
Blautia caccae
Blautia hominis
Blautia luti
Breznakia
Burkholderiales
Butyrivibrio
Caproiciproducens
Caproiciproducens galactitolivorans
Catenibacterium
Catenibacterium mitsuokai
Christensenella
Christensenella massiliensis
Christensenellaceae
Clostridia
Clostridiaceae
Clostridium
Collinsella
Collinsella aerofaciens
Coprococcus
Coprococcus catus
Coprococcus comes
Coprococcus eutactus
Coriobacteriaceae
Deltaproteobacteria
Desulfovibrio
Desulfovibrionaceae
Desulfovibrionales
Dialister
Dialister succinatiphilus
Dorea
Dorea formicigenerans
Dorea longicatena
Duncaniella
Duncaniella freteri
Duodenibacillus
Eggerthellaceae
Eggerthellales
Elusimicrobiaceae
Elusimicrobiales
Elusimicrobiota
Elusimicrobium
Elusimicrobium minutum
Enterobacteriaceae
Enterocloster hominis (ex Hitch et al. 2024)
Erysipelotrichaceae
Erysipelotrichales
Erysipelotrichia
Eshraghiella crossota
Eubacteriaceae
Eubacteriales
Anaerovoracaceae
Eubacterium
Eubacterium coprostanoligenes
Eubacterium ruminantium
Faecalibacterium
Faecalibacterium prausnitzii
Faecalitalea
Faecalitalea cylindroides
Flavonifractor
Flavonifractor plautii
Fusicatenibacter
Fusicatenibacter saccharivorans
Holdemanella
Holdemanella biformis
Hoylesella oralis
Hoylesella shahii
Ihubacter
Ihubacter massiliensis
Kineothrix
Kineothrix alysoides
Lachnoclostridium
Lachnospira
Lachnospira eligens
Lachnospiraceae
Lacrimispora
Lacrimispora xylanolytica
Lactobacillaceae
Lactobacillus
Leptotrichia shahii
Leyella stercorea
Massiliprevotella
Massiliprevotella massiliensis
Mediterraneibacter
Mediterraneibacter faecis
Methanobacteria
Methanobacteriaceae
Methanobacteriales
Methanobacteriota
Methanobrevibacter
Methanobrevibacter smithii
Mitsuokella
Mollicutes
Monoglobus
Monoglobus pectinilyticus
Muribaculaceae
Mycoplasmatota
Odoribacter
Odoribacteraceae
Oscillibacter
Oscillibacter ruminantium
Oscillibacter valericigenes
Oscillospiraceae
Parabacteroides
Parabacteroides merdae
Paraprevotella
Paraprevotella clara
Peptostreptococcaceae
Phocaeicola
Phocaeicola vulgatus
Prevotella
Prevotellaceae
Prevotellamassilia
Pseudobutyrivibrio ruminis
Rickenellaceae
Romboutsia
Romboutsia timonensis
Roseburia
Roseburia inulinivorans
Ruminiclostridium
Ruminococcus
Ruminococcus bromii
Ruminococcus callidus
Ruthenibacterium
Ruthenibacterium lactatiformans
Segatella copri
Segatella oris
Sporobacter
Sporobacter termitidis
Streptococcus thermophilus
Subdoligranulum variabile
Succinivibrio
Succinivibrio dextrinosolvens
Succinivibrionaceae
Sutterella massiliensis
Sutterellaceae
Thomasclavelia
Thomasclavelia spiroformis
Veillonellaceae
Verrucomicrobiales
Verrucomicrobiia
[Eubacterium] siraeum
unclassified Oscillospiraceae
S_sp_str_D16_nov_89_414S_sp_str_D16_nov_89_414
S_bacterium_HMT_086_nov_96_364S_bacterium_HMT_086_nov_96_364
G_Lachnospiraceae_G_7G_Lachnospiraceae_G_7
S_sp_HMT_040_nov_92_918S_sp_HMT_040_nov_92_918
S_sp_str_D13_nov_91_232S_sp_str_D13_nov_91_232
S_sp_str_NML04A032_nov_90_337S_sp_str_NML04A032_nov_90_337
G_multigenusG_multigenus
S_multispeciesspp1_2S_multispeciesspp1_2
S_sp_str_D16_nov_95_495S_sp_str_D16_nov_95_495
S_multispecies_spp51_2S_multispecies_spp51_2
S_sp_str_D16_nov_93_243S_sp_str_D16_nov_93_243
S_bacterium_HMT_911_nov_90_652S_bacterium_HMT_911_nov_90_652
G_Bacteroidetes_G_7_G_Bacteroidetes_G_7_
S_bacterium_HMT_085_nov_90_766S_bacterium_HMT_085_nov_90_766
S_bacterium_HMT_085_nov_92_809S_bacterium_HMT_085_nov_92_809
S_bacterium_HMT_402_nov_91_011S_bacterium_HMT_402_nov_91_011
S_bacterium_HMT_899_nov_93_290S_bacterium_HMT_899_nov_93_290
S_bacterium_HMT_085_nov_91_422S_bacterium_HMT_085_nov_91_422
S_multispecies_spp14_2S_multispecies_spp14_2
S_bacterium_HMT_085_nov_93_946S_bacterium_HMT_085_nov_93_946
S_multispecies_sppn2_2_nov_91_216S_multispecies_sppn2_2_nov_91_216
S_bacterium_HMT_402_nov_90_337S_bacterium_HMT_402_nov_90_337
S_bacterium_HMT_091_nov_93_213S_bacterium_HMT_091_nov_93_213
S_multispecies_spp26_5S_multispecies_spp26_5
S_bacterium_HMT_402 _nov_89 _038S_bacterium_HMT_402 _nov_89 _038
S_multispecies_spp12_2S_multispecies_spp12_2
G_ Peptostreptococcaceae_ XI_G_2G_ Peptostreptococcaceae_ XI_G_2
S_sp_SS3_4S_sp_SS3_4
S_multispecies_sppn27_2_nov_97_959S_multispecies_sppn27_2_nov_97_959
S_multispecies_sppn_2_nov_95_023S_multispecies_sppn_2_nov_95_023
C_Bacteroidetes_C_1_C_Bacteroidetes_C_1_
O_Bacteroidetes_O_1_O_Bacteroidetes_O_1_
F_Bacteroidetes_F_1_F_Bacteroidetes_F_1_
S_multispecies_spp29_2S_multispecies_spp29_2
F_Lachnospiraceae_XIVaF_Lachnospiraceae_XIVa
F_multifamilyF_multifamily
G_Clostridiales_F_1_G_2G_Clostridiales_F_1_G_2
F_Clostridiales_F_1F_Clostridiales_F_1
G_Ruminococcaceae_G_2G_Ruminococcaceae_G_2
O_multiorderO_multiorder
S_sp_HMT_090_nov_92_795S_sp_HMT_090_nov_92_795
Ruminoclostriduim methylpentosumRuminoclostriduim methylpentosum

Revision editor(s): MyleeeA, Aleru Divine, WikiWorks

Experiment 9

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Curated date: 2024/11/05

Curator: Aleru Divine

Revision editor(s): WikiWorks, Aleru Divine, MyleeeA

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Parkinson's disease + Periodontitis group (PA + P) (Feces)

Group 1 name Corresponds to the case (exposed) group for case-control studies

Parkinson's disease + Periodontitis group (PA + P) (Saliva)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Saliva samples collected from Parkinson's disease + Periodontitis group (PA + P) participants.

Group 0 sample size Number of subjects in the control (unexposed) group

16

Group 1 sample size Number of subjects in the case (exposed) group

16

Lab analysis

Statistical Analysis

Signature 1

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Revision editor(s): Aleru Divine, Svetlana up, WikiWorks

Source: Supplementary File 2c

Description: LefSe results representing significant difference in relative abundance in fecal and saliva samples from Periodontitis patients with Parkinson's disease (PA + P).

Abundance in Group 1: increased abundance in Parkinson's disease + Periodontitis group (PA + P) (Saliva)

NCBI	Quality Control	Links
Abiotrophia
Abiotrophia defectiva
Acidimicrobiia
Actinomycetaceae
Actinomycetales
Actinomycetota
Aerococcaceae
Bacillales
Bacilli
Bacteria
Bergeyella
Campylobacter
Campylobacter concisus
Campylobacteraceae
Campylobacterales
Candidatus Absconditabacteria bacterium
Candidatus Altimarinota
Candidatus Saccharibacteria
Capnocytophaga
Carnobacteriaceae
Epsilonproteobacteria
Flavobacteriaceae
Flavobacteriales
Flavobacteriia
Fusobacteriales
Fusobacteriia
Fusobacteriota
Gemella
Gemella haemolysans
Gemella sp.
Gemellaceae
Granulicatella
Haemophilus
Haemophilus parainfluenzae
Lactobacillales
Metamycoplasma faucium
Micrococcaceae
Mogibacterium
Mollicutes
Mycoplasma
Mycoplasmataceae
Mycoplasmatales
Neisseria
Neisseria subflava
Neisseriaceae
Neisseriales
Oscillospiraceae
Parvimonas
Parvimonas micra
Parvimonas sp.
Pasteurellaceae
Pasteurellales
Peptoniphilaceae
Peptostreptococcaceae
Peptostreptococcus
Peptostreptococcus stomatis
Porphyromonas
Porphyromonas pasteri
Prevotella melaninogenica
Rothia
Rothia mucilaginosa
Selenomonas
Slackia
Slackia exigua
Solobacterium
Solobacterium moorei
Spirochaetaceae
Spirochaetales
Spirochaetia
Spirochaetota
Staphylococcaceae
Streptococcaceae
Streptococcus
Streptococcus anginosus
Tannerella
Tannerella forsythia
Tannerellaceae
Tissierella
Tissierellales
Treponema
Treponema denticola
Veillonellaceae
[Eubacterium] brachy
[Eubacterium] sulci
G_Saccharibacteria_TM7_ G_1G_Saccharibacteria_TM7_ G_1
C_ Saccharibacteria_TM7_C_1C_ Saccharibacteria_TM7_C_1
O_ Saccharibacteria_TM7_O_1O_ Saccharibacteria_TM7_O_1
S_multispecies_spp109_2S_multispecies_spp109_2
S_bacterium_HMT_351S_bacterium_HMT_351
S_multispecies_spp134_2S_multispecies_spp134_2
S_bacterium_HMT_352S_bacterium_HMT_352
S_multispecies_spp5_2S_multispecies_spp5_2
S_multispecies_spp118_2S_multispecies_spp118_2
S_bacterium_HMT_075S_bacterium_HMT_075
S_multispecies _spp18_3S_multispecies _spp18_3
S_bacterium_HMT_346S_bacterium_HMT_346
S_multispecies_spp17_4S_multispecies_spp17_4
S_bacterium_HMT_349S_bacterium_HMT_349
S_multispecies spp27 2S_multispecies spp27 2
S_bacterium_HMT_085S_bacterium_HMT_085
S_bacterium_HMT_356S_bacterium_HMT_356
S_bacterium_HMT_346_nov_97_968S_bacterium_HMT_346_nov_97_968
S_multispecies_spp95_4S_multispecies_spp95_4
S_multispecies_spp8_3S_multispecies_spp8_3
G_Bacteroidales_ G_2G_Bacteroidales_ G_2
F_Bacteroidales_ F_2F_Bacteroidales_ F_2
S_ bacterium_HMT_369S_ bacterium_HMT_369
G_ Peptostreptococcaceae_XI_G_4G_ Peptostreptococcaceae_XI_G_4
S_sp_ Oral_Taxon_A55S_sp_ Oral_Taxon_A55
S_ multispecies _spp7_2S_ multispecies _spp7_2
F_multifamilyF_multifamily
G_multigenusG_multigenus
G_Peptostreptococcaceae_XI_G_1G_Peptostreptococcaceae_XI_G_1
F_Saccharibacteria_ TM7_F_2F_Saccharibacteria_ TM7_F_2
S_multispecies_spp_39_5S_multispecies_spp_39_5
S_bacterium_HMT_345S_bacterium_HMT_345
G_Peptostreptocaccaceae_XI_G_9G_Peptostreptocaccaceae_XI_G_9
S_bacterium_HMT_155S_bacterium_HMT_155
S_bacterium_HMT_905S_bacterium_HMT_905
S_bacterium_HMT_280S_bacterium_HMT_280
G_Saccharibacteria_TM7_G_3.G_Saccharibacteria_TM7_G_3.
G_Saccharibacteria_ TM7_G_5G_Saccharibacteria_ TM7_G_5
F_Saccharibacteria_TM7_F_1F_Saccharibacteria_TM7_F_1

Revision editor(s): Aleru Divine, Svetlana up, WikiWorks

Signature 2

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Reviewed Marked as Reviewed by Svetlana up on 2024-11-20

Curated date: 2024/11/06

Curator: MyleeeA

Revision editor(s): MyleeeA, Aleru Divine, WikiWorks

Source: Supplementary File 2

Description: LefSe results representing significant difference in relative abundance in fecal and saliva samples from Periodontitis patients with Parkinson's disease (PA + P).

Abundance in Group 1: decreased abundance in Parkinson's disease + Periodontitis group (PA + P) (Saliva)

NCBI	Quality Control	Links
Abiotrophia sp. HMSC24B09
Acetanaerobacterium
Acetanaerobacterium elongatum
Acutalibacter
Acutalibacter muris
Agathobaculum desmolans
Alcaligenaceae
Alistipes communis
Alistipes finegoldii
Alistipes putredinis
Alistipes shahii
Allofournierella massiliensis
Alloprevotella tannerae
Alteracholeplasma parvum
Anaerobutyricum hallii
Anaeromassilibacillus
Anaeromassilibacillus senegalensis
Anaeroplasmataceae
Anaeroplasmatales
Anaerotignum
Anaerotignum faecicola
Asteroleplasma
Asteroleplasma anaerobium
Bacteroides intestinalis
Barnesiella
Barnesiellaceae
Bilophila
Bilophila wadsworthia
Blautia
Blautia caccae
Blautia intestinihominis
Blautia luti
Blautia sp.
Breznakia
Breznakia pachnodae
Butyricicoccus
Butyricicoccus pullicaecorum
Butyricimonas
Caecibacter massiliensis
Casaltella massiliensis
Christensenella massiliensis
Clostridium
Coprobacter
Coprobacter fastidiosus
Coprococcus catus
Coprococcus eutactus
Defluviitalea
Defluviitaleaceae
Desulfovibrio
Desulfovibrio piger
Dialister succinatiphilus
Dorea formicigenerans
Duodenibacillus
Duodenibacillus massiliensis
Eggerthella
Eggerthella lenta
Eggerthellaceae
Eggerthellales
Enterococcaceae
Enterococcus
Enterococcus faecalis
Eshraghiella crossota
Anaerovoracaceae
Eubacterium
Eubacterium coprostanoligenes
Eubacterium ventriosum
Faecalibacterium prausnitzii
Faecalitalea
Faecalitalea cylindroides
Flavonifractor
Flavonifractor plautii
Fusicatenibacter saccharivorans
Geosporobacter
Geosporobacter ferrireducens
Holdemanella
Holdemanella biformis
Hoylesella oralis
Hoylesella shahii
Ihubacter massiliensis
Intestinibacillus massiliensis
Kineosporiaceae
Kineosporiales
Kineothrix alysoides
Lachnobacterium
Lachnobacterium bovis
Lentisphaeria
Leptotrichia shahii
Limosilactobacillus
Limosilactobacillus mucosae
Mediterraneibacter massiliensis
Megasphaera elsdenii
Megasphaera massiliensis
Monoglobus
Monoglobus pectinilyticus
Odoribacter
Odoribacter splanchnicus
Odoribacteraceae
Oscillibacter
Oscillibacter ruminantium
Oscillibacter valericigenes
Parabacteroides distasonis
Parabacteroides merdae
Paraprevotella
Paraprevotella clara
Parolsenella
Parolsenella catena
Peptostreptococcaceae
Phocaeicola massiliensis
Pseudobutyrivibrio ruminis
Romboutsia
Romboutsia timonensis
Roseburia
Roseburia faecis
Ruminiclostridium
Ruminococcus bromii
Segatella copri
Senegalimassilia
Senegalimassilia anaerobia
Slackia
Slackia isoflavoniconvertens
Sporobacter termitidis
Streptococcus thermophilus
Subdoligranulum variabile
Sutterella
Sutterella wadsworthensis
Thomasclavelia
Thomasclavelia spiroformis
Turicibacter
Turicibacter sanguinis
Turicibacteraceae
Victivallales
Victivallis
Victivallis vadensis
[Collinsella] massiliensis
[Eubacterium] siraeum
S_multispecies_sppn54_2S_multispecies_sppn54_2
G_multigenusG_multigenus
S_multispecies_sppn6_2_nov_91_910S_multispecies_sppn6_2_nov_91_910
S_multispecies_sppn10_2_nov_92_135S_multispecies_sppn10_2_nov_92_135
S_multispecies_sppn7_2_nov_88_964S_multispecies_sppn7_2_nov_88_964
G_Peptostreptococcaceae_XI_G_2G_Peptostreptococcaceae_XI_G_2
S_sp_str_D16_nov_95_495S_sp_str_D16_nov_95_495
S_sp_str_NML04A032_nov_87_416S_sp_str_NML04A032_nov_87_416
S_multispecies_sppn75_2_nov_97_391S_multispecies_sppn75_2_nov_97_391
S_bacterium_HMT_086_nov_936_364S_bacterium_HMT_086_nov_936_364
S_sp_HMT_040_nov_92_918S_sp_HMT_040_nov_92_918
S_multispecies_spp1_2S_multispecies_spp1_2
S_bacterium_HMT_905_nov_92_625S_bacterium_HMT_905_nov_92_625
G_Lachnospiraceae_G_7G_Lachnospiraceae_G_7
S_sp_ Oral_Taxon_A55_nov_87_607S_sp_ Oral_Taxon_A55_nov_87_607
S_sp_ Oral_Taxon_A55_nov_85_439S_sp_ Oral_Taxon_A55_nov_85_439
S_bacterium_HMT_091_nov_93_213S_bacterium_HMT_091_nov_93_213
S_multispecies_sppn12_2_nov_95_692S_multispecies_sppn12_2_nov_95_692
S_multispecies_sppn103_2_nov_94_631S_multispecies_sppn103_2_nov_94_631
S_multispecies_spp51_2S_multispecies_spp51_2
S_multispecies_spp12_2S_multispecies_spp12_2
S_sp_str_D16_nov_93_454S_sp_str_D16_nov_93_454
S_sp_str_NML04A032_nov_92_793S_sp_str_NML04A032_nov_92_793
S_sp_str_NML04A032_nov_90_090S_sp_str_NML04A032_nov_90_090
S_sp_str_D16_nov_89_414S_sp_str_D16_nov_89_414
S_multispecies_sppn68_2_nov_97_279S_multispecies_sppn68_2_nov_97_279
S_multispecies_sppn102_2_nov_95_692S_multispecies_sppn102_2_nov_95_692
S_multispecies_sppn46_2_nov_92_568S_multispecies_sppn46_2_nov_92_568
S_sp_str_L2_50_S_sp_str_L2_50_
S_multispecies_spp19_2S_multispecies_spp19_2
S_bacterium_HMT_085_nov_96_946S_bacterium_HMT_085_nov_96_946
S_sp_str_D16_nov_93_018S_sp_str_D16_nov_93_018
S_Sp_SS3-4S_Sp_SS3-4
S_multispecies_spp14_2S_multispecies_spp14_2
S_multispecies_sppn79_2_nov_83_445S_multispecies_sppn79_2_nov_83_445
S_multispecies_spp68_2S_multispecies_spp68_2
S_multispecies_spp97_6S_multispecies_spp97_6
S_bacterium_HMT_402_nov_91_216S_bacterium_HMT_402_nov_91_216
S_multispecies_sppn1_2_nov_95_023S_multispecies_sppn1_2_nov_95_023
S_multispecies_spp29_2S_multispecies_spp29_2
S_bacterium_HMT_402_nov_91_011S_bacterium_HMT_402_nov_91_011
S_sp_str_D16_nov_93_243S_sp_str_D16_nov_93_243
TuricibacteralesTuricibacterales
F_Lachnospiraceae XIVaF_Lachnospiraceae XIVa
Ruminoclostriduim methylpentosumRuminoclostriduim methylpentosum

Revision editor(s): MyleeeA, Aleru Divine, WikiWorks