Comparative Analysis of the Gut Microbiota of Bat Species with Different Feeding Habits
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Study information
-
Quality control
- Retracted paper
- Contamination issues suspected
- Batch effect issues suspected
- Uncontrolled confounding suspected
- Results are suspect (various reasons)
- Tags applied
study design
Citation
PMID PubMed identifier for scientific articles.
DOI Digital object identifier for electronic documents.
URI
Authors
Mena Canata DA, Benfato MS, Pereira FD, Ramos Pereira MJ, Hackenhaar FS, Mann MB, Frazzon APG, Rampelotto PH
Journal
Biology
Year
2024
Keywords:
diet, frugivore, insectivore, microbiome, nectarivore, vampire bat
Bats are a diverse and ecologically important group of mammals that exhibit remarkable diversity in their feeding habits. These diverse feeding habits are thought to be reflected in the composition and function of their gut microbiota, which plays important roles in nutrient acquisition, immune function, and overall health. Despite the rich biodiversity of bat species in South America, there is a lack of microbiome studies focusing on bats from this region. Such studies could offer major insights into conservation efforts and the preservation of biodiversity in South America. In this work, we aimed to compare the gut microbiota of four bat species with different feeding habits from Southern Brazil, including nectarivorous, frugivorous, insectivorous, and hematophagous bats. Our findings demonstrate that feeding habits can have a significant impact on the diversity and composition of bat gut microbiotas, with each species exhibiting unique metabolic potentials related to their dietary niches. In addition, the identification of potentially pathogenic bacteria suggests that the carriage of microbial pathogens by bats may vary, depending on feeding habits and host-specific factors. These findings provide novel insights into the relationship between bat feeding habits and gut microbiota composition, highlighting the need to promote diverse habitats and food sources to support these ecologically important species.
Experiment 1
Needs review
Curated date: 2024/12/16
Curator:
Revision editor(s):
Subjects
- Location of subjects
- Brazil
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Glossophaga soricina
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Material entity in digestive tract Digestive tract contents,Ingested material entity,Material entity in digestive tract,material entity in digestive tract
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Combination of frugivorous, insectivorous and hematophagous bats.
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Nectarivorous
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Nectarivorous adult male bats caught in southern Brazil. Nectarivorous bats have a specialized nectar based diet, adaptations include long, slender snouts and tongues.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 26
- Group 1 sample size Number of subjects in the case (exposed) group
- 7
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.1
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2.0
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-2-11
Source: "3.3 Microbial Composition" second paragraph text.
Description: LEfSe analysis of bacteria genera from four bat species with different feeding habits.
Abundance in Group 1: increased abundance in
| NCBI | Quality Control | Links |
|---|---|---|
| Actinomyces | ||
| Clostridium | ||
| Terrisporobacter | ||
| Ureaplasma | ||
| unclassified Clostridiaceae | ||
| unclassified Enterobacteriaceae | ||
| unclassified Neisseriaceae |
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-2-11
Source: "3.3 Microbial Composition" second paragraph text.
Description: LEfSe analysis of bacteria genera from four bat species with different feeding habits.
Abundance in Group 1: decreased abundance in
Experiment 2
Needs review
Curated date: 2024/12/18
Curator:
Revision editor(s):
Differences from previous experiment shown
Subjects
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Sturnira lilium
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Combination of nectarivorous, insectivorous and hematophagous bats.
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Frugivorous
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Frugivorous adult male bats caught in southern Brazil. Frugivorous bats have a specialized fruit based diet, adaptations in neo-tropical species include short snouts and strong jaws.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 23
- Group 1 sample size Number of subjects in the case (exposed) group
- 10
Lab analysis
Statistical Analysis
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-2-11
Source: "3.3 Microbial Composition" second paragraph text.
Description: LEfSe analysis of bacteria genera from four bat species with different feeding habits.
Abundance in Group 1: increased abundance in
| NCBI | Quality Control | Links |
|---|---|---|
| Campylobacter | ||
| Helicobacter | ||
| unclassified Acholeplasmataceae |
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-2-11
Source: "3.3 Microbial Composition" second paragraph text.
Description: LEfSe analysis of bacteria genera from four bat species with different feeding habits.
Abundance in Group 1: decreased abundance in
Experiment 3
Differences from previous experiment shown
Subjects
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Molossus molossus
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Combination of frugivorous, nectarivorous and hematophagous bats.
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Insectivorous
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Insectivorous adult male bats caught in southern Brazil. Insectivorous bats have a specialized diet based on arthropods, adaptations include echolocation calls that allow tracking and capturing small fast-moving prey.
Lab analysis
Statistical Analysis
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-2-11
Source: "3.3 Microbial Composition" second paragraph text
Description: LEfSe analysis of bacteria genera from four bat species with different feeding habits.
Abundance in Group 1: increased abundance in Insectivorous
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-2-11
Source: "3.3 Microbial Composition" second paragraph text.
Description: LEfSe analysis of bacteria genera from four bat species with different feeding habits.
Abundance in Group 1: decreased abundance in Insectivorous
Experiment 4
Differences from previous experiment shown
Subjects
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Desmodus rotundus
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Combination of frugivorous, nectarivorous and insectivorous bats.
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Hematophagous
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Hematophagous adult male bats caught in southern Brazil. Hematophagous bats have a blood specilized diet, adaptations include sharp incisors and heat sensors on their noses.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 27
- Group 1 sample size Number of subjects in the case (exposed) group
- 6
Lab analysis
Statistical Analysis
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-2-11
Source: "3.3 Microbial Composition" second paragraph text.
Description: LEfSe analysis of bacteria genera from four bat species with different feeding habits.
Abundance in Group 1: increased abundance in Hematophagous
| NCBI | Quality Control | Links |
|---|---|---|
| Edwardsiella | ||
| Peptostreptococcaceae |
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-2-11
Source: "3.3 Microbial Composition" second paragraph text.
Description: LEfSe analysis of bacteria genera from four bat species with different feeding habits.
Abundance in Group 1: decreased abundance in Hematophagous
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