Metagenomic analysis revealed the association between gut microbiota and different ovary responses to controlled ovarian stimulation/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by KateRasheed on 2025-5-3
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Hormone replacement therapy HORMONE REPLACE THER,Hormone Replacement Therapies,Hormone Replacement Therapy,REPLACE THER HORMONE,Replacement Therapies, Hormone,Replacement Therapy, Hormone,THER HORMONE REPLACE,Therapies, Hormone Replacement,Therapy, Hormone Replacement,Hormone replacement therapy,hormone replacement therapy
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Follicle to Oocyte Index (FOI) >=0.5
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Low Ovarian Sensitivity Follicle to Oocyte Index(FOI)<0.5
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients who were hypo responsive with follicle-to-oocyte index <0.5.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 25
- Group 1 sample size Number of subjects in the case (exposed) group
- 22
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 1 month
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
- unchanged
Signature 1
Reviewed Marked as Reviewed by KateRasheed on 2025-5-3
Source: Figure 3
Description: Significantly different microbiomes between two groups at species level
Abundance in Group 1: increased abundance in Low Ovarian Sensitivity Follicle to Oocyte Index(FOI)<0.5
Revision editor(s): Nithya
Signature 2
Reviewed Marked as Reviewed by KateRasheed on 2025-5-3
Source: Figure 3
Description: Significantly different microbiomes between two groups at species level
Abundance in Group 1: decreased abundance in Low Ovarian Sensitivity Follicle to Oocyte Index(FOI)<0.5
| NCBI | Quality Control | Links |
|---|---|---|
| Bifidobacterium longum | ||
| Actinomyces graevenitzii | ||
| Actinomyces johnsonii | ||
| Actinomyces oris |
Revision editor(s): Nithya
