The impact of small intestinal bacterial overgrowth on the efficacy of fecal microbiota transplantation in patients with chronic constipation/Experiment 3
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-3-24
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Small intestine Anterior intestine,Intestinum tenue,Mid intestine,Small bowel,Small intestine,small intestine
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Response to transplant Response to transplant,response to transplant
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- NegI0-small intestine sample in Small intestinal bacterial overgrowth group (Non-SIBO group) at pre-FMT
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- POSI0-small intestine sample in Small intestinal bacterial overgrowth group (SIBO group) at pre-FMT
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Small intestinal bacterial overgrowth (SIBO) group before FMT
- Group 0 sample size Number of subjects in the control (unexposed) group
- 130
- Group 1 sample size Number of subjects in the case (exposed) group
- 88
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- Extensive antibiotic use
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- -V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- increased
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-3-24
Source: Figure 5A
Description: Gut microbiota differences between the small intestinal microbiota of two groups were identified with a LEfSe analysis with an LDA score threshold >2.0.
Abundance in Group 1: decreased abundance in POSI0-small intestine sample in Small intestinal bacterial overgrowth group (SIBO group) at pre-FMT
Revision editor(s): Miss Lulu
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-3-24
Source: Figure 5A
Description: Gut microbiota differences between the small intestinal microbiota of two groups were identified with a LEfSe analysis with an LDA score threshold >2.0.
Abundance in Group 1: increased abundance in POSI0-small intestine sample in Small intestinal bacterial overgrowth group (SIBO group) at pre-FMT
| NCBI | Quality Control | Links |
|---|---|---|
| Deinococci | ||
| Deinococcota | ||
| Lachnospiraceae | ||
| Lachnospirales | ||
| Meiothermus | ||
| Sphingomonadaceae | ||
| Sphingomonadales | ||
| Sphingomonas | ||
| Thermaceae | ||
| Thermales |
Revision editor(s): Miss Lulu
