Relationships between the Microbiome and Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer/Experiment 4

From BugSigDB


Needs review

Curated date: 2025/05/07

Curator: Tosin

Revision editor(s): Tosin

Subjects

Location of subjects
South Korea
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Rectum Intestinum rectum,Rectal sac,Terminal portion of intestine,Terminal portion of large intestine,Rectum,rectum
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Response to platinum-based neoadjuvant chemotherapy Response to platinum-based neoadjuvant chemotherapy,response to platinum-based neoadjuvant chemotherapy
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Pre-nCRT (Pre-neoadjuvant chemoradiotherapy) Non-responders
Group 1 name Corresponds to the case (exposed) group for case-control studies
Pre-nCRT (Pre-neoadjuvant chemoradiotherapy) Responders
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer within Pre-nCRT (Pre-neoadjuvant chemoradiotherapy) samples
Group 0 sample size Number of subjects in the control (unexposed) group
17
Group 1 sample size Number of subjects in the case (exposed) group
9
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
1 month

Lab analysis

16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
ANOVA
T-Test
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No


Signature 1

Needs review

Curated date: 2025/05/07

Curator: Tosin

Revision editor(s): Tosin

Source: Figure 3B and 3C

Description: Heatmap and relative abundance of pre-nCRT (pre-neoadjuvant chemoradiotherapy) microbiome composition at family and genera level. R, responder; NR, non-responder.

Abundance in Group 1: increased abundance in Pre-nCRT (Pre-neoadjuvant chemoradiotherapy) Responders

NCBI Quality ControlLinks
Lachnospiraceae
Oscillospiraceae
Ruminococcus
Roseburia
Lachnospira
Faecalibacterium

Revision editor(s): Tosin