Associations between the gut microbiome, inflammation and cardiovascular profiles in people with HIV/Experiment 3
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-4-11
Subjects
- Location of subjects
- Ireland
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Alcohol consumption measurement Alcohol consumption measurement,alcohol consumption measurement
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low Alcohol Intake
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High Alcohol Intake
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Higher alcohol consumption recorded in individuals diagnosed with HIV (Human Immunodeficiency Virus)
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- centered log-ratio
- Statistical test
- Spearman Correlation
- ANCOM-BC
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.1
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, sex, antiretroviral therapy, Confounders controlled for: "comorbidities" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.comorbidities, Confounders controlled for: "statins" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.statins
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-4-11
Source: Fig-3
Description: Heatmap showing the correlation of the differentially abundant (DA) species with mean nutrient intake and the Healthy Food Diversity (HFD) index.
Abundance in Group 1: increased abundance in High Alcohol Intake
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroides eggerthii |
Revision editor(s): Aiyshaaaa
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-4-11
Source: Fig-3 And S5
Description: Heatmap showing the correlation of the differentially abundant (DA) species and genues level with mean nutrient intake and the Healthy Food Diversity (HFD) index.
Abundance in Group 1: decreased abundance in High Alcohol Intake
| NCBI | Quality Control | Links |
|---|---|---|
| Bifidobacterium pseudocatenulatum | ||
| Succinivibrio |
Revision editor(s): Aiyshaaaa
