Impact of psychostimulants on microbiota and short-chain fatty acids alterations in children with attention-deficit/hyperactivity disorder/Experiment 6

From BugSigDB


Reviewed Marked as Reviewed by Svetlana up on 2025-3-28

Curated date: 2025/03/23

Curator: Joiejoie

Revision editor(s): Joiejoie

Subjects

Location of subjects
Thailand
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Treatment outcome measurement Treatment outcome measurement,treatment outcome measurement
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Healthy controls
Group 1 name Corresponds to the case (exposed) group for case-control studies
Unmedicated Attention-deficit hyperactivity disorder (ADHD)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group consists of children aged 6–12 years diagnosed with ADHD who have not received psychostimulant medication for their condition.
Group 0 sample size Number of subjects in the control (unexposed) group
10
Group 1 sample size Number of subjects in the case (exposed) group
10
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
2 weeks

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
log transformation
Statistical test
ANCOM-BC
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes
Matched on Factors on which subjects have been matched on in a case-control study
age, sex

Alpha Diversity

Pielou Quantifies how equal the community is numerically
unchanged
Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Richness Number of species
unchanged
Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
increased

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-3-28

Curated date: 2025/03/23

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 2

Description: Differential abundance of gut microbiota among healthy controls and children with unmedicated ADHD.

Abundance in Group 1: increased abundance in Unmedicated Attention-deficit hyperactivity disorder (ADHD)

NCBI Quality ControlLinks
Aerococcaceae
Alphaproteobacteria
Brevundimonas
Caulobacteraceae
Caulobacterales
Corynebacteriaceae
Corynebacterium
Dermacoccaceae
Enhydrobacter
Gemella
Gemellaceae
Haemophilus
Hyphomicrobiales
Kytococcus
Leptotrichiaceae
Micrococcales
Micrococcus
Moraxellaceae
Mycobacteriales
Neisseria
Neisseriaceae
Paracoccaceae
Pasteurellaceae
Pasteurellales
Porphyromonadaceae
Porphyromonas
Propionibacteriaceae
Propionibacteriales
Pseudomonadaceae
Pseudomonadales
Pseudomonas
Rhizobiaceae
Rhodobacterales
Staphylococcaceae
Staphylococcus
Veillonella
unidentified
StaphylococcalesStaphylococcales
Cutibacterium

Revision editor(s): Joiejoie

Signature 2

Reviewed Marked as Reviewed by Svetlana up on 2025-3-28

Curated date: 2025/03/23

Curator: Joiejoie

Revision editor(s): Joiejoie, KateRasheed

Source: Fig. 2

Description: Differential abundance of gut microbiota among healthy controls and children with unmedicated ADHD.

Abundance in Group 1: decreased abundance in Unmedicated Attention-deficit hyperactivity disorder (ADHD)

NCBI Quality ControlLinks
Acetanaerobacterium
Actinomycetota
Anaerobutyricum hallii
Anaerofustis
Anaerostipes
Bacillota
Bacteroidaceae
Bacteroides
Bacteroidia
Bacteroidota
Barnesiella
Barnesiellaceae
Blautia
Candidatus Soleaferrea
Clostridia
Clostridiales bacterium DTU089
Clostridium sp. CAG:352
Collinsella
Coprobacillaceae
Coriobacteriaceae
Coriobacteriaceae incertae sedis
Coriobacteriales
Coriobacteriales bacterium DNF00809
Coriobacteriia
Desulfovibrionia
Eggerthellaceae
Enterobacteriaceae
Eubacteriales
Lachnoclostridium
Lachnospiraceae
Lachnospirales
Lactococcus
Parabacteroides
Peptostreptococcaceae
Slackia
Sutterella
Sutterellaceae
Thermodesulfobacteriota
Tyzzerella
Verrucomicrobiota
[Ruminococcus] torques
AnaerofustaceaeAnaerofustaceae
EthanoligenenaceaeEthanoligenenaceae
Prevotellaceae NK3B31 groupPrevotellaceae NK3B31 group
Prevotellaceae UCG 003Prevotellaceae UCG 003
Lachnospiraceae NC2004 groupLachnospiraceae NC2004 group
Incertae SedisIncertae Sedis
uncultured Coriobacteriaceae incertae sedisuncultured Coriobacteriaceae incertae sedis

Revision editor(s): Joiejoie, KateRasheed