The difference of oropharyngeal microbiome during acute respiratory viral infections in infants and children/Experiment 3

Reviewed Marked as Reviewed by KateRasheed on 2025-6-13

Curated date: 2025/05/04

Curator: Shulamite

Revision editor(s): Shulamite, Anne-mariesharp, KateRasheed

Host species Species from which microbiome was sampled. Contact us to have more species added.: Homo sapiens

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology: Oropharynx Mesopharynx,Oral part of pharynx,Pars oralis pharyngis,Oropharynx,oropharynx

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology: Fatigue Fatigue,Tired,Tiredness,fatigue

Group 0 name Corresponds to the control (unexposed) group for case-control studies: Non-fatigue

Group 1 name Corresponds to the case (exposed) group for case-control studies: Fatigue

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group: Children who exhibited fatigue as part of their clinical presentation of ARI.

16S variable region One or more hypervariable region(s) of the bacterial 16S gene: Not specified

Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance: Illumina

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).: relative abundances

Significance threshold p-value or FDR threshold used for differential abundance testing (if any): 0.05

MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?: Yes

LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool: 2

Matched on Factors on which subjects have been matched on in a case-control study: age, sex

Shannon Estimator of species richness and species evenness: more weight on species richness: decreased

Reviewed Marked as Reviewed by KateRasheed on 2025-6-13

Curated date: 2025/05/04

Curator: Shulamite

Revision editor(s): Shulamite, Anne-mariesharp

Source: Table S4

Description: Differences of taxonomic relative abundance between disease-related symptom groups by LEfSe analysis.

Abundance in Group 1: increased abundance in Fatigue

Revision editor(s): Shulamite, Anne-mariesharp