Effects of vaginal microbiota on in vitro fertilization outcomes in women with different infertility causes/Experiment 5
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-4-8
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Vaginal fluid Vaginal discharge,Vaginal secretion,Vaginal fluid,vaginal fluid
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Polycystic ovary syndrome Cystic disease of ovaries,hyperandrogenemia,Multicystic ovaries,multicystic ovaries,Ovarian Degeneration, Sclerocystic,Ovarian Syndrome, Polycystic,Ovarian Syndromes, Polycystic,Ovaries, Sclerocystic,Ovary Syndrome, Polycystic,Ovary, Sclerocystic,PCO - Polycystic ovaries,Pco1,PCOD - Polycystic ovarian disease,PCOS,Pcos,PCOS - Polycystic ovarian syndrome,PCOS1,Polycystic ovarian disease,polycystic ovarian disease,Polycystic ovarian syndrome,Polycystic ovaries,polycystic ovaries,Polycystic ovaries (disorder),polycystic ovary,polycystic ovary syndrome,polycystic ovary syndrome 1,Sclerocystic Ovarian Degeneration,Sclerocystic Ovaries,Sclerocystic Ovary,Sclerocystic Ovary Syndrome,Stein Leventhal Syndrome,Stein-Leventhal synd.,Stein-Leventhal Syndrome,Stein-Leventhal syndrome,Syndrome, Polycystic Ovary,Syndrome, Stein-Leventhal,Polycystic ovary syndrome
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Polycystic Ovary Syndrome.Pregnant (PCOS.P) group
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Polycystic Ovary Syndrome.Non-pregnant (PCOS.NP) group
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- This group consists of infertile women with Polycystic Ovary Syndrome (PCOS) who are not pregnant.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 10
- Group 1 sample size Number of subjects in the case (exposed) group
- 22
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- unchanged
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-4-8
Source: Figure 5E
Description: Histogram of taxa with differential abundance computed using LDA scores.
Abundance in Group 1: increased abundance in Polycystic Ovary Syndrome.Non-pregnant (PCOS.NP) group
| NCBI | Quality Control | Links |
|---|---|---|
| Mycoplasmataceae | ||
| Veillonellaceae bacterium | ||
| Pseudomonas | ||
| Pseudomonadaceae | ||
| Dialister propionicifaciens |
Revision editor(s): Victoria
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-4-8
Source: Figure 5E
Description: Histogram of taxa with differential abundance computed using LDA scores.
Abundance in Group 1: decreased abundance in Polycystic Ovary Syndrome.Non-pregnant (PCOS.NP) group
| NCBI | Quality Control | Links |
|---|---|---|
| Clostridium sp. | ||
| Leptotrichia sp. |
Revision editor(s): Victoria
