Effects of vaginal microbiota on in vitro fertilization outcomes in women with different infertility causes/Experiment 8

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Svetlana up on 2025-4-8

Curated date: 2025/04/02

Curator: Victoria

Revision editor(s): Victoria

Subjects

Location of subjects

China

Host species Species from which microbiome was sampled. Contact us to have more species added.

Homo sapiens

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology

Vaginal fluid Vaginal discharge,Vaginal secretion,Vaginal fluid,vaginal fluid

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Ectopic pregnancy Ectopic pregnancy,ectopic pregnancy

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Non-ectopic pregnancy group

Group 1 name Corresponds to the case (exposed) group for case-control studies

Ectopic pregnancy group

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

This group consists of women with Tubal factor infertility(TFI) and a history of ectopic pregnancy.

Group 0 sample size Number of subjects in the control (unexposed) group

38

Group 1 sample size Number of subjects in the case (exposed) group

12

Lab analysis

Sequencing type

16S

16S variable region One or more hypervariable region(s) of the bacterial 16S gene

V3-V4

Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance

Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).

relative abundances

Statistical test

Mann-Whitney (Wilcoxon)

Significance threshold p-value or FDR threshold used for differential abundance testing (if any)

0.05

MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?

No

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Svetlana up on 2025-4-8

Curated date: 2025/04/02

Curator: Victoria

Revision editor(s): Victoria

Source: Figure 4H

Description: Boxplot distribution of Lactobacillus abundance classified based on the history of ectopic pregnancy.

Abundance in Group 1: decreased abundance in Ectopic pregnancy group

NCBI	Quality Control	Links
Lactobacillus

Revision editor(s): Victoria