Effects of vaginal microbiota on in vitro fertilization outcomes in women with different infertility causes/Experiment 8

From BugSigDB


Reviewed Marked as Reviewed by Svetlana up on 2025-4-8

Curated date: 2025/04/02

Curator: Victoria

Revision editor(s): Victoria

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Vaginal fluid Vaginal discharge,Vaginal secretion,Vaginal fluid,vaginal fluid
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Ectopic pregnancy Ectopic pregnancy,ectopic pregnancy
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Non-ectopic pregnancy group
Group 1 name Corresponds to the case (exposed) group for case-control studies
Ectopic pregnancy group
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group consists of women with Tubal factor infertility(TFI) and a history of ectopic pregnancy.
Group 0 sample size Number of subjects in the control (unexposed) group
38
Group 1 sample size Number of subjects in the case (exposed) group
12

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
Mann-Whitney (Wilcoxon)
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No


Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-4-8

Curated date: 2025/04/02

Curator: Victoria

Revision editor(s): Victoria

Source: Figure 4H

Description: Boxplot distribution of Lactobacillus abundance classified based on the history of ectopic pregnancy.

Abundance in Group 1: decreased abundance in Ectopic pregnancy group

NCBI Quality ControlLinks
Lactobacillus

Revision editor(s): Victoria