Roseburia hominis improves host metabolism in diet-induced obesity/Experiment 6

From BugSigDB


Needs review

Curated date: 2025/04/11

Curator: Z.uk.a

Revision editor(s): Z.uk.a

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Mus musculus
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Total cholesterol measurement cholesterol, total,total cholesterol levels,Total cholesterol measurement,total cholesterol measurement
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Low total cholesterol
Group 1 name Corresponds to the case (exposed) group for case-control studies
High total cholesterol
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Group 1 consists of mice with High Cholesterol levels.
Group 0 sample size Number of subjects in the control (unexposed) group
5
Group 1 sample size Number of subjects in the case (exposed) group
5

Lab analysis

Sequencing type
WMS
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
Spearman Correlation
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes


Signature 1

Needs review

Curated date: 2025/04/13

Curator: Z.uk.a

Revision editor(s): Z.uk.a

Source: Figure 4E

Description: Total Cholesterol correlation of differential species in mice between HFD-PBS and HFD-RH groups

Abundance in Group 1: increased abundance in High total cholesterol

NCBI Quality ControlLinks
Faecalibaculum rodentium
Romboutsia ilealis
Staphylococcus xylosus
Eggerthella sp. HF 1101Eggerthella sp. HF 1101
Berryella intestinalis

Revision editor(s): Z.uk.a

Signature 2

Needs review

Curated date: 2025/04/13

Curator: Z.uk.a

Revision editor(s): Z.uk.a

Source: Figure 4E

Description: Total Cholesterol correlation differential species in mice between HFD-PBS and HFD-RH groups

Abundance in Group 1: decreased abundance in High total cholesterol

NCBI Quality ControlLinks
Dysosmobacter welbionis
Faecalibacterium prausnitzii
Flavonifractor plautii
Herbinix luporum
Lachnoclostridium sp. YL32
Oscillibacter sp. PEA192
Oscillibacter valericigenes
Parabacteroides goldsteinii
Roseburia hominis
Roseburia intestinalis
Ruthenibacterium lactatiformans
Oscillibacter sp. NSJ 62Oscillibacter sp. NSJ 62
Butyrivibrio fibrisolvens

Revision editor(s): Z.uk.a