Gut microbiome alterations precede graft rejection in kidney transplantation patients/Experiment 11

From BugSigDB


Needs review

Curated date: 2025/04/07

Curator: Victoria

Revision editor(s): Victoria

Subjects

Location of subjects
Germany
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Age Age,age
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Donor Age(10-15)/Decreasing
Group 1 name Corresponds to the case (exposed) group for case-control studies
Donor Age(10-15)/ Increasing
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Participants in this group are donors between the ages of 10 and 15 years.

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
Kruskall-Wallis
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes


Signature 1

Needs review

Curated date: 2025/04/08

Curator: Victoria

Revision editor(s): Victoria

Source: Supplemental Figure S4

Description: Heatmap showing associations of bacterial genera with kidney transplant rejection.

Abundance in Group 1: increased abundance in Donor Age(10-15)/ Increasing

NCBI Quality ControlLinks
Enterococcus

Revision editor(s): Victoria

Signature 2

Needs review

Curated date: 2025/04/08

Curator: Victoria

Revision editor(s): Victoria

Source: Supplementary Figure S4

Description: Heatmap showing associations of bacterial genera with kidney transplant rejection.

Abundance in Group 1: decreased abundance in Donor Age(10-15)/ Increasing

NCBI Quality ControlLinks
[Ruminococcus] torques
Faecalibacterium sp. UBA1819

Revision editor(s): Victoria