Characterization of vaginal microbiomes in clinician-collected bacterial vaginosis diagnosed samples/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by KateRasheed on 2025-8-12
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Vaginal fluid Vaginal discharge,Vaginal secretion,Vaginal fluid,vaginal fluid
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Bacterial vaginosis BACT VAGINITIDES,BACT VAGINITIS,BACT VAGINOSES,BACT VAGINOSIS,Bacterial Vaginitides,Bacterial Vaginitis,Bacterial Vaginoses,bacterial vaginosis,BV,Nonspecific Vaginitis,VAGINITIDES BACT,Vaginitides, Bacterial,VAGINITIS BACT,Vaginitis, Bacterial,Vaginitis, Nonspecific,VAGINOSES BACT,Vaginoses, Bacterial,VAGINOSIS BACT,Vaginosis, Bacterial,Bacterial vaginosis
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Bacterial vaginosis-Negative
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Bacterial vaginosis-Positive
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients diagnosed with Bacterial vaginosis.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 45
- Group 1 sample size Number of subjects in the case (exposed) group
- 27
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- log transformation
- Statistical test
- ANCOM-BC
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Signature 1
Reviewed Marked as Reviewed by KateRasheed on 2025-8-12
Source: Figures 4A and 4B
Description: Differential abundance (DA) analysis and modularized co-occurrence network analysis of BV-POS and BV-NEG samples.
Abundance in Group 1: increased abundance in Bacterial vaginosis-Positive
Signature 2
Reviewed Marked as Reviewed by KateRasheed on 2025-8-12
Source: Figure 4A and 4B
Description: Differential abundance (DA) analysis and modularized co-occurrence network analysis of BV-POS and BV-NEG samples.
Abundance in Group 1: decreased abundance in Bacterial vaginosis-Positive
