Fecal bacterial biomarkers and blood biochemical indicators as potential key factors in the development of colorectal cancer/Experiment 8

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Reviewed Marked as Reviewed by KateRasheed on 2025-4-24

Curated date: 2025/04/11

Curator: Nithya

Revision editor(s): Nithya, Shulamite

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Colorectal cancer cancer of colorectum,cancer of large bowel,cancer of large intestine,cancer of the large bowel,colon cancer,colorectal cancer,colorectum cancer,CRC,large intestine cancer,malignant colorectal neoplasm,malignant colorectal tumor,malignant colorectum neoplasm,malignant large bowel neoplasm,malignant large bowel tumor,malignant large intestine neoplasm,malignant large intestine tumor,malignant neoplasm of colorectum,malignant neoplasm of large bowel,malignant neoplasm of large intestine,malignant neoplasm of the large bowel,malignant neoplasm of the large intestine,malignant tumor of large bowel,malignant tumor of large intestine,malignant tumor of the large bowel,malignant tumor of the large intestine,Colorectal cancer
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Patients with Polyps (P group)
Group 1 name Corresponds to the case (exposed) group for case-control studies
Patients with Colorectal Cancer stage II (C2)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Patients diagonosed with Colorectal Cancer stage II (C2)
Group 0 sample size Number of subjects in the control (unexposed) group
92
Group 1 sample size Number of subjects in the case (exposed) group
101
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
1 Month

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Statistical test
ANOVA
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No

Alpha Diversity

Richness Number of species
decreased

Signature 1

Reviewed Marked as Reviewed by KateRasheed on 2025-4-24

Curated date: 2025/04/11

Curator: Nithya

Revision editor(s): Nithya, KateRasheed

Source: Figure 4 and 2C

Description: Boxplot analysis of key differential genera from diagnosis model and dominant phyla

Abundance in Group 1: increased abundance in Patients with Colorectal Cancer stage II (C2)

NCBI Quality ControlLinks
Gemella
Parvimonas
Peptostreptococcus
Fusobacteriota

Revision editor(s): Nithya, KateRasheed

Signature 2

Reviewed Marked as Reviewed by KateRasheed on 2025-4-24

Curated date: 2025/04/11

Curator: Nithya

Revision editor(s): Nithya

Source: Figure 4 and 2C

Description: Boxplot analysis of key differential genera from diagnosis model and dominant phyla

Abundance in Group 1: decreased abundance in Patients with Colorectal Cancer stage II (C2)

NCBI Quality ControlLinks
Corynebacterium
Ezakiella
Fenollaria
Finegoldia
Peptoniphilus
Staphylococcus
Varibaculum
Pseudomonadota

Revision editor(s): Nithya