Fecal microbiota transplantation restores gut microbiota diversity in children with active Crohn's disease: a prospective trial/Experiment 5
From BugSigDB
Reviewed Marked as Reviewed by KateRasheed on 2025-5-12
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Response to transplant Response to transplant,response to transplant
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- FMT0W (Fecal Microbiota Transplantation before treatment)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- FMT10W (Fecal microbiota transplantation at week 10 after oral capsule treatment)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients given fecal microbiota transplantation treatment after Ten weeks
- Group 0 sample size Number of subjects in the control (unexposed) group
- 17
- Group 1 sample size Number of subjects in the case (exposed) group
- 17
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- increased
- Chao1 Abundance-based estimator of species richness
- increased
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- decreased
- Richness Number of species
- increased
Signature 1
Reviewed Marked as Reviewed by KateRasheed on 2025-5-12
Source: Figure 6A
Description: Relative abundance of the core functional genera between FMT0W (Fecal microbiota transplantation before treatment) and FMT10W (Fecal microbiota transplantation at week 10 after oral capsule treatment) determined using the Wilcoxon rank-sum test.
Abundance in Group 1: increased abundance in FMT10W (Fecal microbiota transplantation at week 10 after oral capsule treatment)
| NCBI | Quality Control | Links |
|---|---|---|
| Agathobacter | ||
| Akkermansia | ||
| Blautia | ||
| Faecalibacterium | ||
| Roseburia | ||
| Subdoligranulum |
