Why do babies cry? Exploring the role of the gut microbiota in infantile colic, constipation, and cramps in the KOALA birth cohort study/Experiment 8
From BugSigDB
Subjects
- Location of subjects
- Netherlands
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Functional abnormality of the gastrointestinal tract Functional abnormality of the GI tract,GI dysfunction,Functional abnormality of the gastrointestinal tract,functional abnormality of the gastrointestinal tract
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low colic: wessel-Covariate adjusted (4 - 7months)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High colic: wessel-Covariate adjusted (4 - 7months)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- High colic: Wessel's criteria applied to infants aged 4–7 months, adjusted for covariates (Full cohort).
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 3 Months.
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- centered log-ratio
- Statistical test
- Logistic Regression
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Richness Number of species
- unchanged
Signature 1
Source: Table S6
Description: Results of regression models testing associations between one-month stool microbiota core genera and functional gastrointestinal symptoms.
Abundance in Group 1: increased abundance in High colic: wessel-Covariate adjusted (4 - 7months)
| NCBI | Quality Control | Links |
|---|---|---|
| Mediterraneibacter gnavus |
Revision editor(s): Shulamite
