Introduction: Dysbiotic changes in the microbiota of the genital tract in candidal vulvovaginitis are manifestedby the formation of associations of Candida fungi with various representatives of opportunistic microfloraagainst the background of Lactobacillus spp. deficiency. In the vast majority of cases, the causative agentof the infection is Candida albicans, with Candida non-albicans being less frequently registered.
Material and methods: To assess the species and quantitative composition of the vaginal microflora inwomen, bacteriological studies were conducted. The research group consisted of 60 women with candidalvulvovaginitis. The control group consisted of 30 healthy women.
Results: The results indicate that in 95% of women with vulvovaginal candidiasis, the vaginal microbiota ischaracterized by the formation of 2–4 component associations of Candida fungi with various representativesof facultatively anaerobic and obligately anaerobic conditionally pathogenic microflora.The speciesspectrum of fungi isolated from the genital tract of women with candidal vulvovaginitis mainly includedC. albicans (75%) and, less frequently, Candida non-albicans (25%). In healthy women, C. albicans wasrecorded in 10% of those examined, and Candida non-albicans in 6.6%.
Conclusions: An increase in the frequency of detection of Candida non-albicans species in the spectrumof fungi isolated from the vagina of women with candidal vulvovaginitis, an increase in the frequency offungal-bacterial associations of microorganisms, as well as a deficiency or absence of Lactobacillus spp.,confirms the importance of constant bacteriological monitoring to identify changes in the composition ofthe vaginal microbiota and prescribe adequate therapy.
Experiment 1
Subjects
- Location of subjects
- Ukraine
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Vagina Distal oviductal region,Distal portion of oviduct,Vaginae,Vagina,vagina
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Vulvovaginal candidiasis Candidal vulvovaginitis,candidal vulvovaginitis,Candidal vulvovaginitis (disorder),Candidal vulvovaginitis NOS (disorder),Candidal: [vulvovaginitis NOS] or [cervix],candidal: [vulvovaginitis NOS] or [cervix],candidal: cervix,Candidiasis of vulva and vagina,candidiasis of vulva and vagina,Candidiasis, Vulvovaginal,Monilial vulvovaginitis,monilial vulvovaginitis,vaginal candidiasis,Vulvovaginal Candidiasis,vulvovaginal candidiasis,Vulvovaginal candidiasis
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy Controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Vulvovaginal candidiasis group
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants in this group were women with Vulvovaginal candidiasis (VVC)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 30
- Group 1 sample size Number of subjects in the case (exposed) group
- 60
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- T-Test
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
Signature 1
Source: Table 1
Description: Candida fungi in patients with vulvovaginal candidiasis
Abundance in Group 1: increased abundance
in
Vulvovaginal candidiasis group
| NCBI | Quality Control | Links |
|---|
| Candida albicans | | |
| Candida tropicalis | | |
| Candida parapsilosis | | |
Revision editor(s): Aleru Divine
Signature 2
Source:
Description:
Abundance in Group 1: | NCBI | Quality Control | Links |
|---|
| | | |
Revision editor(s): Aleru Divine
Experiment 2
Differences from previous experiment shown
Signature 1
Source: Table 2
Description: Microflora of the vagina in patients with candidiasis vulvovaginitis
Abundance in Group 1: increased abundance
in
Vulvovaginal candidiasis group
| NCBI | Quality Control | Links |
|---|
| Staphylococcus epidermidis | | |
| Staphylococcus aureus | | |
| Enterococcus faecalis | | |
| Streptococcus agalactiae | | |
| Escherichia coli | | |
| Klebsiella sp. | | |
| Enterobacter sp. | | |
| Veillonella sp. | | |
Revision editor(s): Aleru Divine
Signature 2
Source: Table 2
Description: Microflora of the vagina in patients with candidiasis vulvovaginitis
Abundance in Group 1: decreased abundance
in
Vulvovaginal candidiasis group
| NCBI | Quality Control | Links |
|---|
| Lactobacillus sp. | | |
| Bifidobacterium sp. | | |
| Bacteroides sp. | | |
| Prevotella sp. | | |
Revision editor(s): Aleru Divine
