Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension/Experiment 1

Needs review

Curated date: 2024/03/28

Curator: PromzyBA

Revision editor(s): PromzyBA, Scholastica

Host species Species from which microbiome was sampled. Contact us to have more species added.: Homo sapiens

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology: Saliva , Subgingival dental plaque Sailva normalis,Saliva atomaris,Saliva molecularis,Salivary gland secretion,Saliva,saliva,Subgingival plaque,Subgingival dental plaque,subgingival dental plaque

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology: Hypertension (hypertensive disease) or (hypertension),[X]Hypertensive diseases,[X]Hypertensive diseases (disorder),Blood Pressure, High,blood pressure, high,blood pressure, increased,Blood Pressures, High,High Blood Pressure,high blood pressure,High blood pressure (& [essential hypertension]),High Blood Pressures,HTN,HTN - hypertension,hyperpiesia,hypertension,hypertension NOS,HYPERTENSIVE DISEASE,hypertensive disease,Hypertensive disease (disorder),hypertensive disease NOS,Hypertensive disease NOS (disorder),hypertensive disorder,increased blood pressure,pressure, high blood,SURG COMP - HYPERTENSION,vascular hypertensive disorder,Hypertension

Group 0 name Corresponds to the control (unexposed) group for case-control studies: Saliva samples

Group 1 name Corresponds to the case (exposed) group for case-control studies: Subgingival plague samples

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group: Subgingival plague samples from participants with Hypertension (HTN); n = 36 and without Hypertension (No HTN); n = 24

Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any): 2 months

16S variable region One or more hypervariable region(s) of the bacterial 16S gene: Not specified

Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance: Illumina

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).: relative abundances

Significance threshold p-value or FDR threshold used for differential abundance testing (if any): 0.05

MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?: Yes

LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool: 2

Shannon Estimator of species richness and species evenness: more weight on species richness: increased

Simpson Estimator of species richness and species evenness: more weight on species evenness: unchanged