Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension/Experiment 5
From BugSigDB
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Subgingival dental plaque Subgingival plaque,Subgingival dental plaque,subgingival dental plaque
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Hypertension (hypertensive disease) or (hypertension),[X]Hypertensive diseases,[X]Hypertensive diseases (disorder),Blood Pressure, High,blood pressure, high,blood pressure, increased,Blood Pressures, High,High Blood Pressure,high blood pressure,High blood pressure (& [essential hypertension]),High Blood Pressures,HTN,HTN - hypertension,hyperpiesia,hypertension,hypertension NOS,HYPERTENSIVE DISEASE,hypertensive disease,Hypertensive disease (disorder),hypertensive disease NOS,Hypertensive disease NOS (disorder),hypertensive disorder,increased blood pressure,pressure, high blood,SURG COMP - HYPERTENSION,vascular hypertensive disorder,Hypertension
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- no-Hypertension (no-HTN)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Hypertension (HTN)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with Hypertension (HTN)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 24
- Group 1 sample size Number of subjects in the case (exposed) group
- 36
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 2 months
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Chao1 Abundance-based estimator of species richness
- unchanged
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- unchanged
- Richness Number of species
- decreased
Signature 1
Source: FIG 3 (B)
Description: Different fungal enrichments between the HTN and no-HTN groups. (b) Subgingival plaques.
Abundance in Group 1: increased abundance in Hypertension (HTN)
Revision editor(s): Rahila
Signature 2
Source: FIG 3 (B)
Description: Different fungal enrichments between the HTN and no-HTN groups. (b) Subgingival plaques.
Abundance in Group 1: decreased abundance in Hypertension (HTN)
Revision editor(s): Rahila
